This paper will explore the reception of Odysseus’ wanderings in twelfth-century Byzantium. Taking into account the Homeric writings of both Eustathius of Thessaloniki and John Tzetzes, I aim to demonstrate that the association between journey and knowledge was extremely productive in the context of the intellectual debates of the time. More specifically, I will show that the development of this traditional theme allowed the major Byzantine scholars to express their own standpoint on crucial matters such as the definition of philosophy, as well as to elaborate on their conception of Homer and their own activity as Homeric exegetes.