Erweiterung der viralen Vektor-Toolbox: das Potenzial von Schimpansen-CMV

Abstract

Human cytomegalovirus (CMV) causes severe disease in immunocompromised individuals. CMV-based vectors are promising candidates in vaccination and immunotherapy approaches. Here, we report on our approach to make chimpanzee CMV (CCMV) available for CMV research and vector development. We cloned the CCMV genome and created a global picture of the CCMV infection program by multi-omics. Via engineering distinct regions in the viral genome, we were able to modify the host cell tropism and immune evasion properties of CCMV.