dc.contributor.author
Phan, Quang Vinh
dc.contributor.author
Bogdanow, Boris
dc.contributor.author
Wiebusch, Lüder
dc.date.accessioned
2025-12-08T11:48:11Z
dc.date.available
2025-12-08T11:48:11Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/50684
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-50411
dc.description.abstract
Human cytomegalovirus (CMV) causes severe disease in immunocompromised individuals. CMV-based vectors are promising candidates in vaccination and immunotherapy approaches. Here, we report on our approach to make chimpanzee CMV (CCMV) available for CMV research and vector development. We cloned the CCMV genome and created a global picture of the CCMV infection program by multi-omics. Via engineering distinct regions in the viral genome, we were able to modify the host cell tropism and immune evasion properties of CCMV.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
gene therapy
en
dc.subject
genetic engineering
en
dc.subject
genetic modification
en
dc.subject
genetic vectors
en
dc.subject
viral vectors
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Erweiterung der viralen Vektor-Toolbox: das Potenzial von Schimpansen-CMV
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1007/s12268-023-1920-0
dcterms.bibliographicCitation.journaltitle
BIOspektrum
dcterms.bibliographicCitation.number
2
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.pagestart
159
dcterms.bibliographicCitation.pageend
161
dcterms.bibliographicCitation.volume
29
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
0947-0867
dcterms.isPartOf.eissn
1868-6249
