The self-consistent Born approximation quantitatively fails to capture disorder effects in semimetals. We present an alternative, simple-to-use nonperturbative approach to calculate the disorder-induced self-energy. It requires a sufficient broadening of the quasiparticle pole and the solution of a differential equation on the imaginary frequency axis. We demonstrate the performance of our method for various paradigmatic semimetal Hamiltonians and compare our results to exact numerical reference data. For intermediate and strong disorder, our approach yields quantitatively correct momentum-resolved results. It is thus complementary to existing renormalization group treatments of weak disorder in semimetals.

We consider the Kondo effect, arising from a hydrogen impurity in graphene. As a first approximation, the strong covalent bond to a carbon atom removes that carbon atom without breaking the C3 rotation symmetry, and we retain only the Hubbard interaction on the three nearest neighbors of the removed carbon atom which then behave as magnetic impurities. These three impurity spins are coupled to three conduction channels with definite helicity, two of which support a diverging local density of states (LDOS) ∝1/[|ω|ln2(Λ/|ω|)] near the Dirac point ω→0 even though the bulk density of states vanishes linearly. We study the resulting three-impurity multichannel Kondo model using the numerical renormalization group method. For weak potential scattering, the ground state of the Kondo model is a particle-hole symmetric spin-1/2 doublet, with ferromagnetic coupling between the three impurity spins; for moderate potential scattering, the ground state becomes a particle-hole asymmetric spin singlet, with antiferromagnetic coupling between the three impurity spins. This behavior is inherited by the Anderson model containing the hydrogen impurity and all four carbon atoms in its vicinity.

We study the robustness of 3D intrinsic topogical order under external perturbations by investigating the paradigmatic microscopic model, the 3D toric code in an external magnetic field. Exact dualities as well as variational calculations reveal a ground-state phase diagram with first and second-order quantum phase transitions. The variational approach can be applied without further approximations only for certain field directions. In the general field case, an approximative scheme based on an expansion of the variational energy in orders of the variational parameters is developed. For the breakdown of the 3D intrinsic topological order, it is found that the (im-)mobility of the quasiparticle excitations is crucial in contrast to their fractional statistics.

We investigate a well‐preserved paleo subduction channel that preserves a coherent part of the European continental margin exposed in the central Tauern Window (Eastern Alps), with the aim of testing models of sheath fold nappe formation and exhumation. The subduction zone was active during Paleogene convergence of the European and Adriatic plates, after closure of the Alpine Tethyan ocean. New cross sections and structural data together with new petrological data document a recumbent, tens of kilometers‐scale sheath fold in the center of the Tauern Window that formed during pervasive top‐foreland shear while subducted at high‐pressure (HP) conditions (~2.0 GPa, 500 °C) close to maximum burial depth. The fold comprises an isoclinally folded thrust that transported relicts of the former Alpine Tethys onto a distal part of the former European continental margin. The passive margin stratigraphy is still well preserved in the fold and highlights the special character of this segment of the European continental margin. We argue that this segment formed a promontory to the margin, which was inherited from Mesozoic rifting. In accordance with classical sheath fold theory, this promontory may have acted as an initial structural perturbation to nucleate a fold that was passively amplified to a sheath fold during top‐foreland shear in the subduction zone. The fold was at least partly exhumed and juxtaposed with the surrounding lower pressure units by opposing top‐hinterland and top‐foreland shear zones above and below, respectively, that is, in the sense of a nappe fold formed during channel‐extrusion exhumation.

Creatinine and proteinuria are used to monitor kidney transplant patients. However, renal biopsies are needed to diagnose renal graft rejection. Here, we assessed whether the quantification of different urinary cells would allow non-invasive detection of rejection. Urinary cell numbers of CD4+ and CD8+ T cells, monocytes/macrophages, tubular epithelial cells (TEC), and podocalyxin(PDX)-positive cells were determined using flow cytometry and were compared to biopsy results. Urine samples of 63 renal transplant patients were analyzed. Patients with transplant rejection had higher amounts of urinary T cells than controls; however, patients who showed worsening graft function without rejection had similar numbers of T cells. T cells correlated with histological findings (interstitial inflammation p = 0.0005, r = 0.70; tubulitis p = 0.006, r = 0.58). Combining the amount of urinary T cells and TEC, or T cells and PDX+ cells, yielded a significant segregation of patients with rejection from patients without rejection (all p < 0.01, area under the curve 0.89-0.91). Urinary cell populations analyzed by flow cytometry have the potential to introduce new monitoring methods for kidney transplant patients. The combination of urinary T cells, TEC, and PDX-positive cells may allow non-invasive detection of transplant rejection.

CD33 is a myeloid-associated marker and belongs to the sialic acid-binding immunoglobulin (Ig)-like lectin (Siglec) family. Such types of receptors are highly expressed in acute myeloid leukemia, which could be used in its treatment. CD33 shows high variability in its expression levels with still unknown reasons. Here, we investigated the CD33 expression of monocytes in human blood samples processed at different temperatures and in dependence on their phagocytic activity against opsonized Escherichia coli. The samples were stained by fluorescently labelled anti-human CD14 to specify the monocyte population, anti-human CD33 antibodies to evaluate CD33 expression and analyzed by flow cytometry and confocal laser scanning microscopy. In blood samples kept at 37°C or first pre-chilled at 0°C with subsequent warming up to 37°C, the percentage of CD33-positive monocytes as well as their relative fluorescence intensity was up-regulated compared to samples kept constantly at 0°C. After exposure to E. coli the CD33 relative fluorescence intensity of the monocytes activated at 37°C was 3 to 4 times higher than that of those cells kept inactive at 0°C. Microscopic analysis showed internalisation of CD33 due to its enhanced expression on the surface followed by engulfment of E. coli.

Short‐duration, high‐impact precipitation events in the extratropics are invariably convective in nature, typically occur during the summer, and are projected to intensify under climate change. The occurrence of convective precipitation is strongly regulated by the diurnal convective cycle, peaking in the late afternoon. Here we perform very high resolution (convection‐permitting) regional climate model simulations to study the scaling of extreme precipitation under climate change across the diurnal cycle. We show that the future intensification of extreme precipitation has a strong diurnal signal and that intraday scaling far in excess of overall scaling, and indeed thermodynamic expectations, is possible. We additionally show that, under a strong climate change scenario, the probability maximum for the occurrence of heavy to extreme precipitation may shift from late afternoon to the overnight/morning period. We further identify the thermodynamic and dynamic mechanisms which modify future extreme environments, explaining both the future scaling's diurnal signal and departure from thermodynamic expectations.

Identification of countermeasures able to prevent disuse-induced muscle wasting is crucial to increase performance of crew members during space flight as well as ameliorate patient's clinical outcome after long immobilization periods. We report on the outcome of short but high-impact reactive jumps (JUMP) as countermeasure during 60 days of 6° head-down tilt (HDT) bed rest on myofiber size, type composition, capillarization, and oxidative capacity in tissue biopsies (pre/post/recovery) from the knee extensor vastus lateralis (VL) and deep calf soleus (SOL) muscle of 22 healthy male participants (Reactive jumps in a sledge, RSL-study 2015-2016, DLR:envihab, Cologne). Bed rest induced a slow-to-fast myofiber shift (type I ->II) with an increased prevalence of hybrid fibers in SOL after bed rest without jumps (control, CTRL, p = 0.016). In SOL, JUMP countermeasure in bed rest prevented both fast and slow myofiber cross-sectional area (CSA) decrements (p = 0.005) in CTRL group. In VL, bed rest only induced capillary rarefaction, as reflected by the decrease in local capillary-to-fiber ratio (LCFR) for both type II (pre vs. post/R + 10, p = 0.028/0.028) and type I myofibers (pre vs. R + 10, p = 0.012), which was not seen in the JUMP group. VO2 max Fiber (pL × mm-1 × min-1) calculated from succinate dehydrogenase (SDH)-stained cryosections (OD660 nm) showed no significant differences between groups. High-impact jump training in bed rest did not prevent disuse-induced myofiber atrophy in VL, mitigated phenotype transition (type I - >II) in SOL, and attenuated capillary rarefaction in the prime knee extensor VL however with little impact on oxidative capacity changes.

Emotion regulation impacts the expected emotional responses to the outcomes of risky decisions via activation of cognitive control strategies. However, whether the regulation of emotional responses to preceding, incidental stimuli also impacts risk-taking in subsequent decisions is still poorly understood. In this study, we investigated the interplay between the regulation of incidentally induced emotional responses and subsequent choice behavior using a risky decision-making task in two independent samples (behavioral and functional magnetic resonance imaging experiment). We found that overall, emotion regulation was followed by less risky decisions, which was further reflected in an increase in activation in brain regions in dorsolateral and ventrolateral prefrontal cortex and cingulate cortex. These findings suggest that altering incidental emotions using reappraisal strategies impacts on subsequent risk-taking in decision-making.

The enantiomer-level isolation of single-walled carbon nanotubes (SWCNTs) in high concentration and with high purity for nanotubes greater than 1.1 nm in diameter is demonstrated using a two-stage aqueous two-phase extraction (ATPE) technique. In total, five different nanotube species of ∼1.41 nm diameter are isolated, including both metallics and semiconductors. We characterize these populations by absorbance spectroscopy, circular dichroism spectroscopy, resonance Raman spectroscopy, and photoluminescence mapping, revealing and substantiating mod-dependent optical dependencies. Using knowledge of the competitive adsorption of surfactants to the SWCNTs that controls partitioning within the ATPE separation, we describe an advanced acid addition methodology that enables the fine control of the separation of these select nanotubes. Furthermore, we show that endohedral filling is a previously unrecognized but important factor to ensure a homogeneous starting material and further enhance the separation yield, with the best results for alkane-filled SWCNTs, followed by empty SWCNTs, with the intrinsic inhomogeneity of water-filled SWCNTs causing them to be worse for separations. Lastly, we demonstrate the potential use of these nanotubes in field-effect transistors.

Proton translocation across membranes is vital to all kingdoms of life. Mechanistically, it relies on characteristic proton flows and modifications of hydrogen bonding patterns, termed protonation dynamics, which can be directly observed by fast magic angle spinning (MAS) NMR. Here, we demonstrate that reversible proton displacement in the active site of bacteriorhodopsin already takes place in its equilibrated dark-state, providing new information on the underlying hydrogen exchange processes. In particular, MAS NMR reveals proton exchange at D85 and the retinal Schiff base, suggesting a tautomeric equilibrium and thus partial ionization of D85. We provide evidence for a proton cage and detect a preformed proton path between D85 and the proton shuttle R82. The protons at D96 and D85 exchange with water, in line with ab initio molecular dynamics simulations. We propose that retinal isomerization makes the observed proton exchange processes irreversible and delivers a proton towards the extracellular release site.

Quantum simulators allow to explore static and dynamical properties of otherwise intractable quantum many-body systems. In many instances, however, the read-out limits such quantum simulations. In this work, we introduce an innovative experimental read-out exploiting coherent non-interacting dynamics. Specifically, we present a tomographic recovery method allowing to indirectly measure the second moments of the relative density fluctuations between two one-dimensional superfluids, which until now eluded direct measurements. Applying methods from signal processing, we show that we can reconstruct the relative density fluctuations from non-equilibrium data of the relative phase fluctuations. We employ the method to investigate equilibrium states, the dynamics of phonon occupation numbers and even to predict recurrences. The method opens a new window for quantum simulations with one-dimensional superfluids, enabling a deeper analysis of their equilibration and thermalization dynamics.

The discovery of the enhancement of Raman scattering by molecules adsorbed on nanostructured metal surfaces is a landmark in the history of spectroscopic and analytical techniques. Significant experimental and theoretical effort has been directed toward understanding the surface-enhanced Raman scattering (SERS) effect and demonstrating its potential in various types of ultrasensitive sensing applications in a wide variety of fields. In the 45 years since its discovery, SERS has blossomed into a rich area of research and technology, but additional efforts are still needed before it can be routinely used analytically and in commercial products. In this Review, prominent authors from around the world joined together to summarize the state of the art in understanding and using SERS and to predict what can be expected in the near future in terms of research, applications, and technological development. This Review is dedicated to SERS pioneer and our coauthor, the late Prof. Richard Van Duyne, whom we lost during the preparation of this article.

In this paper we suggest an understanding of the self within the conceptual framework of situated affectivity, proposing the notion of an affectively extended self and arguing that the construction, diachronic re-shaping and maintenance of the self is mediated first by affective interactions. We initially consider the different variations on the conception of the extended self that have been already proposed in the literature (Clark & Chalmers 1998; Heersmink 2017, 2018; Krueger 2018; Wilson, Lenart 2015). We then propose our alternative, contextualising it within the current debate on situated affectivity. While the idea that we exploit the external environment in order to manage our affective life is now rather widespread among philosophers (e.g. Colombetti & Krueger 2015, Piredda 2019), its potential consequences for and connections with the debate on the self remain underexplored. Drawing on James’ intuition of the “material self”, which clearly connects the self and the emotions in agency, and broadly envisioning an extension of the self beyond its organismic boundaries, we propose our pragmatist conception of the self: an affectively extended self that relies on affective artifacts and practices to construct its identity extended beyond skin and skull.

Aim: A study was conducted to evaluate the ameliorative potential of homeopathic drugs in combination (Sulfur 30C, Thuja 30C, Graphites 30C, and Psorinum 30C) in 16 dogs affected with oral papillomatosis which was not undergone any previous treatment. Materials and Methods: Dogs affected with oral papillomatosis, which have not undergone any initial treatment and fed with a regular diet. Dogs (total=16) were randomly divided into two groups, namely, homeopathic treatment group (n=8) and placebo control group (n=8). Random number table was used for allocation. Homeopathic combination of drugs and placebo drug (distilled water) was administered orally twice daily for 15 days. Clinical evaluation in both groups of dogs was performed by the same investigator throughout the period of study (12 months). Dogs were clinically scored for oral lesions on days 0, 5, 7, 10, 15, 20, 25, 30, 45, 60, 90, 120, and 150 after initiation of treatment. Results: The homeopathic treatment group showed early recovery with a significant reduction in oral lesions reflected by clinical score (p<0.001) in comparison to placebo-treated group. Oral papillomatous lesions regressed in the homeopathic group between 7 and 15 days, whereas regression of papilloma in the placebo group occurred between 90 and 150 days. The homeopathic treated group was observed for 12 months post-treatment period and no recurrence of oral papilloma was observed. Conclusion: The current study proves that the combination of homeopathy drugs aids in fastening the regression of canine oral papilloma and proved to be safe and cost-effective.