Title:
Characterization of hitherto unknown Valsartan photodegradation impurities
Author(s):
Kurzawa, Timon; Fazzani, Salim; Tempel, Rene; Helmboldt, Hannes; Bleschke, Christian; Kohlmann, Andreas; Hagenbach, Adelheid
Year of publication:
2023
Available Date:
2023-02-07T14:07:15Z
Abstract:
A detailed investigation of Valsartan`s light-induced degradation is reported. Based on UPLC-HRMS studies of stressed solutions several degradation pathways are proposed. Some of the proposed structures were obtained by forced degradation experiments. Examination of analytical data including crystal structures allowed for structural revision of one literature-known degradant. In addition, irradiation under aerobic conditions revealed further degradative pathways leading to two previously unknown decomposition products. Mechanistic considerations regarding their origin helped to identify structural weak points of Valsartan under the influence of light.
Part of Identifier:
e-ISSN (online): 1872-8014
Keywords:
Valsartan
Photodegradation
Potential impurities
DDC-Classification:
540 Chemie und zugeordnete Wissenschaften
Publication Type:
Wissenschaftlicher Artikel
URL of the Original Publication:
DOI of the Original Publication:
Journaltitle:
Journal of Molecular Structure
Department/institution:
Biologie, Chemie, Pharmazie
Institut für Chemie und Biochemie
