dc.contributor.author
Kurzawa, Timon
dc.contributor.author
Fazzani, Salim
dc.contributor.author
Tempel, Rene
dc.contributor.author
Helmboldt, Hannes
dc.contributor.author
Bleschke, Christian
dc.contributor.author
Kohlmann, Andreas
dc.contributor.author
Hagenbach, Adelheid
dc.date.accessioned
2023-02-07T14:07:15Z
dc.date.available
2023-02-07T14:07:15Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/37881
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-37594
dc.description.abstract
A detailed investigation of Valsartan`s light-induced degradation is reported. Based on UPLC-HRMS studies of stressed solutions several degradation pathways are proposed. Some of the proposed structures were obtained by forced degradation experiments. Examination of analytical data including crystal structures allowed for structural revision of one literature-known degradant. In addition, irradiation under aerobic conditions revealed further degradative pathways leading to two previously unknown decomposition products. Mechanistic considerations regarding their origin helped to identify structural weak points of Valsartan under the influence of light.
en
dc.format.extent
8 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Photodegradation
en
dc.subject
Potential impurities
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
Characterization of hitherto unknown Valsartan photodegradation impurities
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
134599
dcterms.bibliographicCitation.doi
10.1016/j.molstruc.2022.134599
dcterms.bibliographicCitation.journaltitle
Journal of Molecular Structure
dcterms.bibliographicCitation.volume
1275
dcterms.bibliographicCitation.url
https://doi.org/10.1016/j.molstruc.2022.134599
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1872-8014
refubium.resourceType.provider
WoS-Alert