dc.contributor.author
Albrecht, Annemarie
dc.contributor.author
Porthun, Jan
dc.contributor.author
Eucker, Jan
dc.contributor.author
Coats, Andrew J.S.
dc.contributor.author
Haehling, Stephan von
dc.contributor.author
Pezzutto, Antonio
dc.contributor.author
Karakas, Mahir
dc.contributor.author
Riess, Hanno
dc.contributor.author
Keller, Ulrich
dc.contributor.author
Landmesser, Ulf
dc.contributor.author
Haverkamp, Wilhelm
dc.contributor.author
Anker, Stefan D.
dc.contributor.author
Anker, Markus S.
dc.date.accessioned
2021-11-10T10:38:25Z
dc.date.available
2021-11-10T10:38:25Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32650
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-32374
dc.description.abstract
Aims: It is largely unknown whether cancer patients seen in routine care show ventricular arrhythmias in 24 h electrocardiograms (ECGs), and whether when they are detected they carry prognostic relevance.
Methods and Results: We included 261 consecutive cancer patients that were referred to the department of cardiology for 24 h ECG examination and 35 healthy controls of similar age and sex in the analysis. To reduce selection bias, cancer patients with known left ventricular ejection fraction <45% were not included in the analysis. Non-sustained ventricular tachycardia (NSVT) episodes of either >= 3 and >= 4 beats duration were more frequent in cancer patients than controls (17% vs. 0%, p = 0.0008; 10% vs. 0%, p = 0.016). Premature ventricular contractions (PVCs)/24 h were not more frequent in cancer patients compared to controls (median (IQR), 26 (2-360) vs. 9 (1-43), p = 0.06; >= 20 PVCs 53% vs. 37%, p = 0.07). During follow-up, (up to 7.2 years, median 15 months) of the cancer patients, 158 (61%) died (1-/3-/5-year mortality rates: 45% [95%CI 39-51%], 66% [95%CI 59-73%], 73% [95%CI 64-82%]). Both non-sustained ventricular tachycardia of >= 4 beats and >= 20 PVCs/24 h independently predicted mortality in univariate and multivariate survival analyses, adjusted for all other univariate predictors of mortality as well as relevant clinical factors, including cancer stage and type, performance status (ECOG), prior potentially cardiotoxic anti-cancer drug therapy, coronary artery disease, potassium concentration, and haemoglobin (multivariate adjusted hazard ratios: NSVT >= 4 beats [HR 1.76, p = 0.022], >= 20 PVCs/24 h [HR 1.63, p < 0.0064]).
Conclusions: NSVT >= 4 beats and >= 20 PVCs/day seen in routine 24 h ECGs of patients with cancer carry prognostic relevance.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
ventricular arrhythmia
en
dc.subject
non-sustained ventricular tachycardia
en
dc.subject
ventricular premature contractions
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Spontaneous Non-Sustained Ventricular Tachycardia and Premature Ventricular Contractions and Their Prognostic Relevance in Patients with Cancer in Routine Care
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
2303
dcterms.bibliographicCitation.doi
10.3390/cancers13102303
dcterms.bibliographicCitation.journaltitle
Cancers
dcterms.bibliographicCitation.number
10
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
13
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
34065780
dcterms.isPartOf.eissn
2072-6694