The last glaciation period, known as the Wisconsin glaciation in North America and the Weichselian glaciation in North Central Europe (NCE), sculpted distinctive landscape features across these regions, including kettle holes in NCE and prairie potholes in the North America’s Prairie Pothole Region (PPR). These depressions, formed by retreating glaciers, hold significant hydrological and ecological importance, and conservation interest. The primary aim of this review article is to compare the similarities and differences between kettle holes in NCE and prairie potholes in the PPR, particularly concerning their ecohydrological characteristics, which have not been thoroughly compared or documented. By clarifying these distinctions, we can gain a better understanding of their unique features. This, in turn, enables wetland scientists to propose tailored management strategies to policymakers and decision-makers for conservation efforts. Our review explores, in particular, kettle holes/prairie potholes’ roles in water storage, nutrient cycling, and habitat provision. We also discuss the impact of anthropogenic activities, such as agricultural and land management practices, on the ecological integrity of these wetlands and propose strategies for their conservation and sustainable management. By elucidating the intricate interplay between geological history, hydrological processes, and ecological dynamics, this article provides valuable insights for researchers, policymakers, and conservation practitioners working towards the preservation of these globally significant wetland habitats. Our synthesis underscores the critical need for interdisciplinary research efforts and integrated management approaches to address the conservation challenges facing prairie potholes and kettle holes in the context of ongoing environmental changes and increasing human pressures.