dc.contributor.author
Behrens, Wiebke
dc.contributor.author
Kolte, Baban
dc.contributor.author
Junker, Vera
dc.contributor.author
Frentrup, Martinique
dc.contributor.author
Dolsdorf, Claudia
dc.contributor.author
Börger, Maria
dc.contributor.author
Jaleta, Megarsa
dc.contributor.author
Kabelitz, Tina
dc.contributor.author
Amon, Thomas
dc.contributor.author
Werner, Doreen
dc.date.accessioned
2023-10-19T07:02:50Z
dc.date.available
2023-10-19T07:02:50Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/41189
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-40910
dc.description.abstract
The regular use of antimicrobials in livestock production selects for antimicrobial resistance. The potential impact of this practice on human health needs to be studied in more detail, including the role of the environment for the persistence and transmission of antimicrobial-resistant bacteria. During an investigation of a pig farm and its surroundings in Brandenburg, Germany, we detected abundant cephalosporin- and fluoroquinolone-resistant Escherichia coli in pig faeces, sedimented dust, and house flies (Musca domestica). Genome sequencing of E. coli isolates revealed large phylogenetic diversity and plasmid-borne extended-spectrum beta lactamase (ESBL) genes CTX-M-1 in multiple strains. [Correction added on 28 February 2023, after first online publication: In the preceding sentence, ‘and TEM-1’ was previously included but has been deleted in this version.] Close genomic relationships indicated frequent transmission of antimicrobial-resistant E. coli between pigs from different herds and across buildings of the farm and suggested dust and flies as vectors for dissemination of faecal pathogens. Strikingly, we repeatedly recovered E. coli from flies collected up to 2 km away from the source, whose genome sequences were identical or closely related to those from pig faeces isolates, indicating the fly-associated transport of diverse ESBL-producing E. coli from the pig farm into urban habitation areas. The observed proximity of contaminated flies to human households poses a risk of transmission of antimicrobial-resistant enteric pathogens from livestock to man.
en
dc.format.extent
12 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Escherichia coli
en
dc.subject
antimicrobial resistance
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
dc.title
Bacterial genome sequencing tracks the housefly-associated dispersal of fluoroquinolone- and cephalosporin-resistant Escherichia coli from a pig farm
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1111/1462-2920.16352
dcterms.bibliographicCitation.journaltitle
Environmental Microbiology
dcterms.bibliographicCitation.number
6
dcterms.bibliographicCitation.pagestart
1174
dcterms.bibliographicCitation.pageend
1185
dcterms.bibliographicCitation.volume
25
dcterms.bibliographicCitation.url
https://doi.org/10.1111/1462-2920.16352
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Tier- und Umwelthygiene
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1462-2920
refubium.resourceType.provider
WoS-Alert