dc.contributor.author
Schüler, Rita
dc.contributor.author
Markova, Mariya
dc.contributor.author
Osterhoff, Martin A.
dc.contributor.author
Arafat, Ayman
dc.contributor.author
Pivovarova, Olga
dc.contributor.author
Machann, Jürgen
dc.contributor.author
Hierholzer, Johannes
dc.contributor.author
Hornemann, Silke
dc.contributor.author
Rohn, Sascha
dc.contributor.author
Pfeiffer, Andreas F. H.
dc.date.accessioned
2023-08-01T12:20:37Z
dc.date.available
2023-08-01T12:20:37Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/40303
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-40024
dc.description.abstract
Increased animal but not plant protein intake has been associated with increased mortality in epidemiological studies in humans and with reduced lifespan in animal species. Protein intake increases the activity of the IGF-1 system which may provide a link to reduced lifespan. We, therefore, compared the effects of animal versus plant protein intake on circulating levels of IGF-1 and the IGF-binding proteins (IGFBP)-1 and IGFBP-2 over a 6-week period. Thirty seven participants with type 2 diabetes consumed isocaloric diets composed of either 30% energy (EN) animal or plant protein, 30% EN fat and 40% EN carbohydrates for 6 weeks. The participants were clinically phenotyped before and at the end of the study. Both diets induced similar and significant increases of IGF-1 which was unaffected by the different amino acid compositions of plant and animal protein. Despite improvements of insulin sensitivity and major reductions of liver fat, IGFBP2 decreased with both diets while IGFBP-1 was not altered. We conclude that animal and plant protein similarly increase IGF-1 bioavailability while improving metabolic parameters and may be regarded as equivalent in this regard.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Protein intake
en
dc.subject
Growth hormone
en
dc.subject
Insulin-like growth factor-1
en
dc.subject
IGF-binding protein-1
en
dc.subject
IGF-binding protein-2
en
dc.subject
Plant protein
en
dc.subject
Animal protein
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Similar dietary regulation of IGF-1- and IGF-binding proteins by animal and plant protein in subjects with type 2 diabetes
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1007/s00394-021-02518-y
dcterms.bibliographicCitation.journaltitle
European Journal of Nutrition
dcterms.bibliographicCitation.number
6
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.pagestart
3499
dcterms.bibliographicCitation.pageend
3504
dcterms.bibliographicCitation.volume
60
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33686453
dcterms.isPartOf.issn
1436-6207
dcterms.isPartOf.eissn
1436-6215