Objectives: Multiparametric MRI with Prostate Imaging Reporting and Data System (PI-RADS) assessment is sensitive but not specific for detecting clinically significant prostate cancer. This study validates the diagnostic accuracy of the recently suggested fractal dimension (FD) of perfusion for detecting clinically significant cancer.
Materials and methods: Routine clinical MR imaging data, acquired at 3 T without an endorectal coil including dynamic contrast-enhanced sequences, of 72 prostate cancer foci in 64 patients were analyzed. In-bore MRI-guided biopsy with International Society of Urological Pathology (ISUP) grading served as reference standard. Previously established FD cutoffs for predicting tumor grade were compared to measurements of the apparent diffusion coefficient (25th percentile, ADC(25)) and PI-RADS assessment with and without inclusion of the FD as separate criterion.
Results: Fractal analysis allowed prediction of ISUP grade groups 1 to 4 but not 5, with high agreement to the reference standard (kappa(FD) = 0.88 [CI: 0.79-0.98]). Integrating fractal analysis into PI-RADS allowed a strong improvement in specificity and overall accuracy while maintaining high sensitivity for significant cancer detection (ISUP > 1; PI-RADS alone: sensitivity = 96%, specificity = 20%, area under the receiver operating curve [AUC] = 0.65; versus PI-RADS with fractal analysis: sensitivity = 95%, specificity = 88%, AUC = 0.92, p < 0.001). ADC(25) only differentiated low-grade group 1 from pooled higher-grade groups 2-5 (kappa(ADC) = 0.36 [CI: 0.12-0.59]). Importantly, fractal analysis was significantly more reliable than ADC(25) in predicting non-significant and clinically significant cancer (AUC(FD) = 0.96 versus AUC(ADC) = 0.75, p < 0.001). Diagnostic accuracy was not significantly affected by zone location.
Conclusions: Fractal analysis is accurate in noninvasively predicting tumor grades in prostate cancer and adds independent information when implemented into PI-RADS assessment. This opens the opportunity to individually adjust biopsy priority and method in individual patients.
