dc.contributor.author
Ronicke, Simon
dc.contributor.author
Osmanodja, Bilgin
dc.contributor.author
Budde, Klemens
dc.contributor.author
Jens, Annika
dc.contributor.author
Hammett, Charlotte
dc.contributor.author
Koch, Nadine
dc.contributor.author
Zukunft, Bianca
dc.contributor.author
Bachmann, Friederike
dc.contributor.author
Choi, Mira
dc.contributor.author
Weber, Ulrike
dc.contributor.author
Eberspächer, Bettina
dc.contributor.author
Hofmann, Jörg
dc.contributor.author
Grunow, Fritz
dc.contributor.author
Mikhailov, Michael
dc.contributor.author
Halleck, Fabian
dc.contributor.author
Schrezenmeier, Eva
dc.date.accessioned
2023-03-28T13:52:25Z
dc.date.available
2023-03-28T13:52:25Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/38638
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-38354
dc.description.abstract
The immunogenicity of SARS-CoV-2 vaccines in kidney transplant recipients is limited, resulting in inadequately low serological response rates and low immunoglobulin (Ig) levels, correlating with reduced protection against death and hospitalization from COVID-19. We retrospectively examined the time course of anti-SARS-CoV-2 Ig antibody levels after up to five repeated vaccinations in 644 previously nonresponding kidney transplant recipients. Using anti SARS-CoV-2 IgG/IgA ELISA and the total Ig ECLIA assays, we compared antibody levels at 1 month with levels at 2 and 4 months, respectively. Additionally, we correlated the measurements of the used assays. Between 1 and 2 months, and between 1 and 4 months, mean anti-SARS-CoV-2 Ig levels in responders decreased by 14% and 25%, respectively, depending on the assay. Absolute Ig values and time course of antibody levels showed high interindividual variability. Ig levels decreased by at least 20% in 77 of 148 paired samples with loss of sufficient serological protection over time occurring in 18 out of 148 (12.2%). IgG ELISA and total Ig ECLIA assays showed a strong positive correlation (Kendall's tau = 0.78), yet the two assays determined divergent results in 99 of 751 (13.2%) measurements. IgG and IgA assays showed overall strong correlation but divergent results in 270 of 1.173 (23.0%) cases and only weak correlation of antibody levels in positive samples. Large interindividual variability and significant loss of serological response after 4 months supports repeated serological sampling and consideration of shorter vaccination intervals in kidney transplant recipients.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
immunogenicity
en
dc.subject
kidney transplantation
en
dc.subject
immunosuppression
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Declining Course of Humoral Immune Response in Initially Responding Kidney Transplant Recipients after Repeated SARS-CoV-2 Vaccination
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
3291
dcterms.bibliographicCitation.doi
10.3390/jcm11123291
dcterms.bibliographicCitation.journaltitle
Journal of Clinical Medicine
dcterms.bibliographicCitation.number
12
dcterms.bibliographicCitation.originalpublishername
MDPI
dcterms.bibliographicCitation.volume
11
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
35743365
dcterms.isPartOf.eissn
2077-0383