dc.contributor.author
Zenzes, Michael
dc.contributor.author
Zaslansky, Paul
dc.date.accessioned
2023-01-18T12:33:26Z
dc.date.available
2023-01-18T12:33:26Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/37683
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-37398
dc.description.abstract
Micro-CT provides critical data for musculoskeletal research, yielding three-dimensional datasets containing distributions of mineral density. Using high-resolution scans, we quantified changes in the fine architecture of bone in the spine of young mice. This data is made available as a reference to physiological cancellous bone growth. The scans (n = 19) depict the extensive structural changes typical for female C57BL/6 mice pups, aged 1-, 3-, 7-, 10- and 14-days post-partum, as they attain the mature geometry. We reveal the micro-morphology down to individual trabeculae in the spine that follow phases of mineral-tissue rearrangement in the growing lumbar vertebra on a micrometer length scale. Phantom data is provided to facilitate mineral density calibration. Conventional histomorphometry matched with our micro-CT data on selected samples confirms the validity and accuracy of our 3D scans. The data may thus serve as a reference for modeling normal bone growth and can be used to benchmark other experiments assessing the effects of biomaterials, tissue growth, healing, and regeneration.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
female C57BL/6 mice
en
dc.subject
lumbar spine
en
dc.subject
Micro-CT data
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Micro-CT data of early physiological cancellous bone formation in the lumbar spine of female C57BL/6 mice
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
132
dcterms.bibliographicCitation.doi
10.1038/s41597-021-00913-y
dcterms.bibliographicCitation.journaltitle
Scientific Data
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.volume
8
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33990616
dcterms.isPartOf.eissn
2052-4463