Haupttitel:
VaporSPOT: Parallel Synthesis of Oligosaccharides on Membranes
Autor*in:
Tsouka, Alexandra; Dallabernardina, Pietro; Mende, Marco; Sletten, Eric T.; Leichnitz, Sabrina; Bienert, Klaus; Hoang, Kim Le Mai; Seeberger, Peter H.; Loeffler, Felix F.
Datum der Freigabe:
2023-01-09T13:39:14Z
Abstract:
Automated chemical synthesis has revolutionized synthetic access to biopolymers in terms of simplicity and speed. While automated oligosaccharide synthesis has become faster and more versatile, the parallel synthesis of oligosaccharides is not yet possible. Here, a chemical vapor glycosylation strategy (VaporSPOT) is described that enables the simultaneous synthesis of oligosaccharides on a cellulose membrane solid support. Different linkers allow for flexible and straightforward cleavage, purification, and characterization of the target oligosaccharides. This method is the basis for the development of parallel automated glycan synthesis platforms.
Teil des Identifiers:
e-ISSN (online): 1520-5126
Freie Schlagwörter:
Chemical structure
Chemical synthesis
Membranes
Oligosaccharides
Post-translational modification
DDC-Klassifikation:
540 Chemie und zugeordnete Wissenschaften
Publikationstyp:
Wissenschaftlicher Artikel
Zeitschrift:
Journal of the American Chemical Society
Fachbereich/Einrichtung:
Biologie, Chemie, Pharmazie
Institut für Chemie und Biochemie