dc.contributor.author
Tsouka, Alexandra
dc.contributor.author
Dallabernardina, Pietro
dc.contributor.author
Mende, Marco
dc.contributor.author
Sletten, Eric T.
dc.contributor.author
Leichnitz, Sabrina
dc.contributor.author
Bienert, Klaus
dc.contributor.author
Hoang, Kim Le Mai
dc.contributor.author
Seeberger, Peter H.
dc.contributor.author
Loeffler, Felix F.
dc.date.accessioned
2023-01-09T13:39:14Z
dc.date.available
2023-01-09T13:39:14Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/37540
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-37254
dc.description.abstract
Automated chemical synthesis has revolutionized synthetic access to biopolymers in terms of simplicity and speed. While automated oligosaccharide synthesis has become faster and more versatile, the parallel synthesis of oligosaccharides is not yet possible. Here, a chemical vapor glycosylation strategy (VaporSPOT) is described that enables the simultaneous synthesis of oligosaccharides on a cellulose membrane solid support. Different linkers allow for flexible and straightforward cleavage, purification, and characterization of the target oligosaccharides. This method is the basis for the development of parallel automated glycan synthesis platforms.
en
dc.format.extent
6 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Chemical structure
en
dc.subject
Chemical synthesis
en
dc.subject
Oligosaccharides
en
dc.subject
Post-translational modification
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
VaporSPOT: Parallel Synthesis of Oligosaccharides on Membranes
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1021/jacs.2c07285
dcterms.bibliographicCitation.journaltitle
Journal of the American Chemical Society
dcterms.bibliographicCitation.number
43
dcterms.bibliographicCitation.pagestart
19832
dcterms.bibliographicCitation.pageend
19837
dcterms.bibliographicCitation.volume
144
dcterms.bibliographicCitation.url
https://doi.org/10.1021/jacs.2c07285
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1520-5126
refubium.resourceType.provider
WoS-Alert