Given that entrepreneurs face substantial adversity in initiating and developing new ventures, a burgeoning stream of research has sought to understand the concept of entrepreneurs’ psychological resilience. To structure and synthesize what we know about entrepreneurs’ psychological resilience, we systematically review the empirical literature to provide insights on how it has been conceptualized and operationalized, along with its key antecedents and outcomes. Based on our review, we advance a promising agenda for future research, grounded in connecting the psychological resilience of entrepreneurs to other research areas connected to the new venture development process. Overall, we point to the urgent need for theoretical precision to enhance the utility of empirical contributions, suggest promising research designs, expand on the important role of adversity, discuss potential boundary conditions, elaborate on the link between entrepreneurs’ psychological resilience and organizational resilience, and address the potential dark side of resilience.