The current western margin of the South American continent is an active subduction orogeny, which is famous for the ’Andean-type’ subduction. The Andes orogeny extends more than 6000 km along the margin. The Central Andes is governed by plateau-style deformation and the subduction of the Nazca plate below Chile and western Argentina, which has caused drastic crustal shortening and thickening, magmatism and periodical back-arc lithosphere and lower crust delamination. The deformation is also influenced by the periodical dip angle variations of the Nazca plate. However, the interaction zone between the overriding plate and the subducting Nazca slab is still enigmatic. In my dissertation, I use earthquake multi-scale full waveform inversion (FWI) to image the crust and upper mantle structure providing new robust images to resolve the interactions between the slab and the Central Andean plateau. First, I performed FWI using 117 earthquakes to investigate the seismic structure for the northern Central Andes which cover the normal-dip subduction zone from southern Peru to central Chile, proceeding from long period data (40–80 s) over several steps down to 12–60 s. In this study, the subducting Nazca slab is clearly imaged in the upper mantle, with dip-angle variations from the north to the south. Bands of low velocities in the crust and mantle wedge indicate intense crustal partial melting and hydration of the mantle wedge beneath the frontal volcanic arc, respectively. They are also linked to the vigorous dehydration from the subducting Nazca plate and intermediate-depth seismicity within the slab. These low-velocity bands are interrupted at 19.8 –21 S, both in the crust and uppermost mantle with an absence of active volcanoes, hinting at the lower extent of crustal partial melting and hydration of the mantle wedge, associated with the weak dehydration from the Nazca plate. The variation of lithospheric high-velocity anomalies below the backarc from north to south allows insight into the evolutionary foundering stages of the Central Andes. An extended high-velocity layer at lithospheric depths beneath the southern Altiplano suggests underthrusting of the leading edge of the Brazilian Shield following the removal of the autochthonous lithosphere. In contrast, a steeply westward dipping high-velocity block and low-velocity lithospheric uppermost mantle beneath the southern Puna plateau hints at the ongoing lithospheric delamination. Second, I took advantage of 134 events to perform FWI and started from even longer period data 60- 120 s to 12-100 s. In this study, a new seismic velocity model for the southern Central Andes is derived, covering the Pampean flat and adjacent Payenia steep subduction segments. Strong focused crustal low-velocity anomalies indicate partial melts in the Payenia segment along the volcanic arc, whereas weaker low-velocity anomalies covering a wide zone in Pampean possibly indicate remnant melts in the past. Thinning and tearing of the flat Nazca slab below the Pampean is inferred by gaps in the high-velocity slab along the inland projection of the Juan-Fernandez-Ridge. A high-velocity anomaly in the upper mantle below the flat slab is interpreted as a relic Nazca slab segment, which indicates an earlier slab break-off during the flattening process, triggered by the buoyancy of the Juan-Fernandez-Ridge. In Payenia, large-scale low-velocity anomalies atop and below the re-steepened Nazca slab are associated with the re-opening of the mantle wedge and sub-slab asthenospheric flow, respectively.