dc.contributor.author
Klein, Oliver
dc.contributor.author
Fogt, Franz
dc.contributor.author
Hollerbach, Stephan
dc.contributor.author
Nebrich, Grit
dc.contributor.author
Boskamp, Tobias
dc.contributor.author
Wellmann, Axel
dc.date.accessioned
2022-03-11T11:54:18Z
dc.date.available
2022-03-11T11:54:18Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/34366
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-34084
dc.description.abstract
Purpose:
Discrimination between ulcerative colitis (UC) and Crohn's disease (CD) by histologic features alone can be challenging and often leads to inaccurate initial diagnoses in inflammatory bowel disease (IBD) patients. This is mostly due to an overlap of clinical and histologic features. However, exact diagnosis is not only important for patient treatment but it also has a socioeconomic impact. It is therefore important to develop and improve diagnostic tools complementing traditional histomorphological approaches.
Experimental Design:
In this retrospective proof-of-concept study, the utilization of MALDI imaging is explored in combination with multi-variate data analysis methods to classify formalin-fixed, paraffin-embedded (FFPE) colon biopsies from UC (87 biopsies, 14 patients), CD (71 biopsies, 14 patients), and normal colonic (21 biopsies, 14 patients) tissues.
Results:
The proposed method results in an overall balanced accuracy of 85.7% on patient and of 80.4% on sample level, thus demonstrating that the assessment of IBD from FFPE tissue specimens via MALDI imaging is feasible.
Conclusions and Clinical Relevance:
The results emphasize the high potential of this method to distinguish IBD subtypes in FFPE tissue sections, which is a prerequisite for further investigations in retrospective multicenter studies, as well as for a future implementation into clinical routine.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Crohn's disease
en
dc.subject
imaging mass spectrometry
en
dc.subject
inflammatory bowel disease
en
dc.subject
ulcerative colitis
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Classification of Inflammatory Bowel Disease from Formalin‐Fixed, Paraffin‐Embedded Tissue Biopsies via Imaging Mass Spectrometry
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1900131
dcterms.bibliographicCitation.doi
10.1002/prca.201900131
dcterms.bibliographicCitation.journaltitle
Proteomics – Clinical Applications
dcterms.bibliographicCitation.number
6
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.volume
14
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32691971
dcterms.isPartOf.issn
1862-8346
dcterms.isPartOf.eissn
1862-8354