dc.contributor.author
Pach, Szymon
dc.date.accessioned
2022-03-01T09:06:08Z
dc.date.available
2022-03-01T09:06:08Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/34082
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-33800
dc.description.abstract
Viral infections represent an old threat to global health, with multiple epidemics and pandemics in the history of mankind. Despite several advances in the development of antiviral substances and vaccines, many viral species are still not targeted. Additionally, new viral species emerge, posing a menace without precedent to humans and animals and causing fatalities, disabilities, environmental harm, and economic losses.
In this thesis, we present rational modeling approaches for targeting specific protease-substrate and protein-protein interactions pivotal for the viral replication cycle. Over the course of this work, antiviral research is supported beginning with the development of small molecular antiviral substances, going through the modeling of a potential immunogenic epitope for vaccine development, towards the establishment of descriptors for susceptibility of animals to a viral infection. Notably, all the research was done under scarce data availability, highlighting the predictive power of computational methods and complementarity between in-silico and in-vitro or in-vivo methods.
en
dc.format.extent
155 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Pharmacophore
en
dc.subject
Protein-protein interactions
en
dc.subject
Protease inhibitors
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik
dc.title
Mechanistic Elucidation of Protease–Substrate and Protein–Protein Interactions for Targeting Viral Infections
dc.contributor.gender
male
dc.contributor.firstReferee
Wolber, Gerhard
dc.contributor.furtherReferee
Goffinet, Christine
dc.date.accepted
2022-02-15
dc.identifier.urn
urn:nbn:de:kobv:188-refubium-34082-3
refubium.affiliation
Biologie, Chemie, Pharmazie
dcterms.accessRights.dnb
free
dcterms.accessRights.openaire
open access