dc.contributor.author
Finger, Anna‐Marie
dc.contributor.author
Kramer, Achim
dc.date.accessioned
2022-01-14T14:17:34Z
dc.date.available
2022-01-14T14:17:34Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/33550
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-33271
dc.description.abstract
Humans and other mammalian species possess an endogenous circadian clock system that has evolved in adaptation to periodically reoccurring environmental changes and drives rhythmic biological functions, as well as behavioural outputs with an approximately 24-hour period. In mammals, body clocks are hierarchically organized, encompassing a so-called pacemaker clock in the hypothalamic suprachiasmatic nucleus (SCN), non-SCN brain and peripheral clocks, as well as cell-autonomous oscillators within virtually every cell type. A functional clock machinery on the molecular level, alignment among body clocks, as well as synchronization between endogenous circadian and exogenous environmental cycles has been shown to be crucial for our health and well-being. Yet, modern life constantly poses widespread challenges to our internal clocks,for exampleartificial lighting, shift work and trans-meridian travel, potentially leading to circadian disruption or misalignment and the emergence of associated diseases. For instance many of us experience a mismatch between sleep timing on work and free days (social jetlag) in our everyday lives without being aware of health consequences that may arise from such chronic circadian misalignment, Hence, this review provides an overview of the organization and molecular built-up of the mammalian circadian system, its interactions with the outside world, as well as pathologies arising from circadian disruption and misalignment.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
circadian disruption
en
dc.subject
circadian misalignment
en
dc.subject
circadian morbidities
en
dc.subject
mammalian circadian clocks
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Mammalian circadian systems: Organization and modern life challenges
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e13548
dcterms.bibliographicCitation.doi
10.1111/apha.13548
dcterms.bibliographicCitation.journaltitle
Acta Physiologica
dcterms.bibliographicCitation.number
3
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.volume
231
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32846050
dcterms.isPartOf.eissn
1748-1716