dc.contributor.author
Zhang, Shuo
dc.contributor.author
Sella, Mauro
dc.contributor.author
Sianturi, Julinton
dc.contributor.author
Priegue, Patricia
dc.contributor.author
Shen, Dacheng
dc.contributor.author
Seeberger, Peter H.
dc.date.accessioned
2021-08-03T06:21:58Z
dc.date.available
2021-08-03T06:21:58Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/31490
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31222
dc.description.abstract
Streptococcus suis bacteria are one of the most serious health problems for pigs and an emerging zoonotic agent in humans working in the swine industry. S. suis bacteria express capsular polysaccharides (CPS) a major bacterial virulence factor that define the serotypes. Oligosaccharides resembling the CPS of S. suis serotypes 2, 3, 9, and 14 have been synthesized, glycans related to serotypes 2 and 9 were placed on glycan array surfaces to screen blood from infected pigs. Lead antigens for the development of semi-synthetic S. suis serotypes 2 and 9 glycoconjugate veterinary vaccines were identified in this way.
en
dc.format.extent
14 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
carbohydrates
en
dc.subject
oligosaccharides
en
dc.subject
total synthesis
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
Discovery of Oligosaccharide Antigens for Semi-Synthetic Glycoconjugate Vaccine Leads against Streptococcus suis Serotypes 2, 3, 9 and 14
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1002/anie.202103990
dcterms.bibliographicCitation.journaltitle
Angewandte Chemie International Edition
dcterms.bibliographicCitation.number
26
dcterms.bibliographicCitation.pagestart
14679
dcterms.bibliographicCitation.pageend
14692
dcterms.bibliographicCitation.volume
60
dcterms.bibliographicCitation.url
https://doi.org/10.1002/anie.202103990
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1521-3773
refubium.resourceType.provider
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