Title:
Discovery of Oligosaccharide Antigens for Semi-Synthetic Glycoconjugate Vaccine Leads against Streptococcus suis Serotypes 2, 3, 9 and 14
Author(s):
Zhang, Shuo; Sella, Mauro; Sianturi, Julinton; Priegue, Patricia; Shen, Dacheng; Seeberger, Peter H.
Year of publication:
2021
Available Date:
2021-08-03T06:21:58Z
Abstract:
Streptococcus suis bacteria are one of the most serious health problems for pigs and an emerging zoonotic agent in humans working in the swine industry. S. suis bacteria express capsular polysaccharides (CPS) a major bacterial virulence factor that define the serotypes. Oligosaccharides resembling the CPS of S. suis serotypes 2, 3, 9, and 14 have been synthesized, glycans related to serotypes 2 and 9 were placed on glycan array surfaces to screen blood from infected pigs. Lead antigens for the development of semi-synthetic S. suis serotypes 2 and 9 glycoconjugate veterinary vaccines were identified in this way.
Part of Identifier:
e-ISSN (online): 1521-3773
Keywords:
carbohydrates
glycans
immunology
oligosaccharides
total synthesis
DDC-Classification:
540 Chemie und zugeordnete Wissenschaften
Publication Type:
Wissenschaftlicher Artikel
URL of the Original Publication:
DOI of the Original Publication:
Journaltitle:
Angewandte Chemie International Edition
Department/institution:
Biologie, Chemie, Pharmazie
Institut für Chemie und Biochemie
