The paper contains analyses of attempts at explaining the profound changes in Eastern Europe after 1989. The analyses are guided by the conceptual framework of social interaction. It covers the micro, meso and macro level of the social organization. The first target is the theory of transition. The diagnosis reveals some constructive features of the theory together with its difficulties to get operationalized and effectively used in explanations. The major deficit of the theory is the absence of a concept of society. Based on the concept of social interaction the conceptual framework of societal transformation efficiently functions as a heuristic tool and as an organizer of knowledge. Is the societal transformations conceptual framework sufficient for a full-fledged explanation of the reform processes in Eastern Europe? The search for an answer leads to increasing relevance of the region’s involvement in the globalization. The conclusion is that the impact of global trends should be integrated in the explanatory procedures of the continuing transformation of Eastern European societies.