Interaction in Mediterranean protohistory is generally considered via the core-periphery model, with greater influence being ascribed to the complex polities of the eastern Mediterranean than to those of the Aegean and central Mediterranean. This is despite archaeological evidence attesting that they actively participated in material and cultural exchanges. In this paper, we focus on Minoan Crete and Mycenaean Greece, reflecting on their interaction spheres and on the meaning of ‘central’ and ‘peripheral’ places. We consider two case studies: Thera and the Aeolian Islands. These islands functioned as maritime hubs in both inter-regional and regional networks. We propose a model of ‘cycles of integration’, as a more accurate and less static representation of interaction.