dc.contributor.author
Lettow, Maike
dc.contributor.author
Grabarics, Márkó
dc.contributor.author
Mucha, Eike
dc.contributor.author
Thomas, Daniel A.
dc.contributor.author
Polewski, Łukasz
dc.contributor.author
Freyse, Joanna
dc.contributor.author
Rademann, Jörg
dc.contributor.author
Meijer, Gerard
dc.contributor.author
Helden, Gert von
dc.contributor.author
Pagel, Kevin
dc.date.accessioned
2020-05-14T13:38:52Z
dc.date.available
2020-05-14T13:38:52Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/27513
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-27269
dc.description.abstract
Glycosaminoglycans (GAGs) are a physio- and pharmacologically highly relevant class of complex saccharides, possessing a linear sequence and strongly acidic character. Their repetitive linear core makes them seem structurally simple at first glance, yet differences in sulfation and epimerization lead to an enormous structural diversity with only a few GAGs having been successfully characterized to date. Recent infrared action spectroscopic experiments on sulfated mono- and disaccharide ions show great promise. Here, we assess the potential of two types of gas-phase action spectroscopy approaches in the range from 1000 to 1800 cm−1 for the structural analysis of complex GAG oligosaccharides. Synthetic tetra- and pentasaccharides were chosen as model compounds for this benchmark study. Utilizing infrared multiple photon dissociation action spectroscopy at room temperature, diagnostic bands are largely unresolved. In contrast, cryogenic infrared action spectroscopy of ions trapped in helium nanodroplets yields resolved infrared spectra with diagnostic features for monosaccharide composition and sulfation pattern. The analysis of GAGs could therefore significantly benefit from expanding the conventional MS-based toolkit with gas-phase cryogenic IR spectroscopy.
en
dc.format.extent
5 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
glycosaminoglycans
en
dc.subject
fondaparinux
en
dc.subject
mass spectrometry
en
dc.subject
action spectroscopy
en
dc.subject
cryogenic infrared spectroscopy
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::547 Organische Chemie
dc.title
IR action spectroscopy of glycosaminoglycan oligosaccharides
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1007/s00216-019-02327-7
dcterms.bibliographicCitation.journaltitle
Analytical & bioanalytical chemistry
dcterms.bibliographicCitation.pagestart
533
dcterms.bibliographicCitation.pageend
537
dcterms.bibliographicCitation.volume
412
dcterms.bibliographicCitation.url
https://doi.org/10.1007/s00216-019-02327-7
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie / Organische Chemie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1618-2642
refubium.resourceType.provider
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