dc.contributor.author
Roth, Sophie
dc.contributor.author
Markó, Lajos
dc.contributor.author
Birukov, Anna
dc.contributor.author
Hennemuth, Anja
dc.contributor.author
Kühnen, Peter
dc.contributor.author
Jones, Alexander
dc.contributor.author
Ghorbani, Niky
dc.contributor.author
Linz, Peter
dc.contributor.author
Müller, Dominik N.
dc.contributor.author
Wiegand, Susanna
dc.contributor.author
Berger, Felix
dc.contributor.author
Kuehne, Titus
dc.contributor.author
Kelm, Marcus
dc.date.accessioned
2020-01-21T12:03:39Z
dc.date.available
2020-01-21T12:03:39Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/26479
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-26239
dc.description.abstract
Early-onset obesity is known to culminate in type 2 diabetes, arterial hypertension and subsequent cardiovascular disease. The role of sodium (Na+) homeostasis in this process is incompletely understood, yet correlations between Na+ accumulation and hypertension have been observed in adults. We aimed to investigate these associations in adolescents. A cohort of 32 adolescents (13-17 years), comprising 20 obese patients, of whom 11 were hypertensive, as well as 12 age-matched controls, underwent 23Na-MRI of the left lower leg with a standard clinical 3T scanner. Median triceps surae muscle Na+ content in hypertensive obese (11.95 mmol/L [interquartile range 11.62-13.66]) was significantly lower than in normotensive obese (13.63 mmol/L [12.97-17.64]; p = 0.043) or controls (15.37 mmol/L [14.12-16.08]; p = 0.012). No significant differences were found between normotensive obese and controls. Skin Na+ content in hypertensive obese (13.33 mmol/L [11.53-14.22] did not differ to normotensive obese (14.12 mmol/L [13.15-15.83]) or controls (11.48 mmol/L [10.48-12.80]), whereas normotensive obese had higher values compared to controls (p = 0.004). Arterial hypertension in obese adolescents is associated with low muscle Na+ content. These findings suggest an early dysregulation of Na+ homeostasis in cardiometabolic disease. Further research is needed to determine whether this association is causal and how it evolves in the transition to adulthood.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
hypertension
en
dc.subject
MR-spectroscopy
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Tissue Sodium Content and Arterial Hypertension in Obese Adolescents
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
2036
dcterms.bibliographicCitation.doi
10.3390/jcm8122036
dcterms.bibliographicCitation.journaltitle
Journal of Clinical Medicine
dcterms.bibliographicCitation.number
12
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
8
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31766426
dcterms.isPartOf.eisbn
2077-0383