id,collection,dc.contributor.author,dc.date.accessioned,dc.date.available,dc.date.issued,dc.description.abstract[en],dc.identifier.uri,dc.language,dc.rights.uri,dc.subject.ddc,dc.subject[en],dc.title,dc.type,dcterms.accessRights.openaire,dcterms.bibliographicCitation.articlenumber,dcterms.bibliographicCitation.doi,dcterms.bibliographicCitation.journaltitle,dcterms.bibliographicCitation.number,dcterms.bibliographicCitation.originalpublishername,dcterms.bibliographicCitation.pmid,dcterms.bibliographicCitation.volume,dcterms.isPartOf.eisbn,refubium.affiliation,refubium.resourceType.isindependentpub "fbce6df0-3d99-4eca-adc1-0038f1e85837","fub188/15","Roth, Sophie||Markó, Lajos||Birukov, Anna||Hennemuth, Anja||Kühnen, Peter||Jones, Alexander||Ghorbani, Niky||Linz, Peter||Müller, Dominik N.||Wiegand, Susanna||Berger, Felix||Kuehne, Titus||Kelm, Marcus","2020-01-21T12:03:39Z","2020-01-21T12:03:39Z","2019","Early-onset obesity is known to culminate in type 2 diabetes, arterial hypertension and subsequent cardiovascular disease. The role of sodium (Na+) homeostasis in this process is incompletely understood, yet correlations between Na+ accumulation and hypertension have been observed in adults. We aimed to investigate these associations in adolescents. A cohort of 32 adolescents (13-17 years), comprising 20 obese patients, of whom 11 were hypertensive, as well as 12 age-matched controls, underwent 23Na-MRI of the left lower leg with a standard clinical 3T scanner. Median triceps surae muscle Na+ content in hypertensive obese (11.95 mmol/L [interquartile range 11.62-13.66]) was significantly lower than in normotensive obese (13.63 mmol/L [12.97-17.64]; p = 0.043) or controls (15.37 mmol/L [14.12-16.08]; p = 0.012). No significant differences were found between normotensive obese and controls. Skin Na+ content in hypertensive obese (13.33 mmol/L [11.53-14.22] did not differ to normotensive obese (14.12 mmol/L [13.15-15.83]) or controls (11.48 mmol/L [10.48-12.80]), whereas normotensive obese had higher values compared to controls (p = 0.004). Arterial hypertension in obese adolescents is associated with low muscle Na+ content. These findings suggest an early dysregulation of Na+ homeostasis in cardiometabolic disease. Further research is needed to determine whether this association is causal and how it evolves in the transition to adulthood.","https://refubium.fu-berlin.de/handle/fub188/26479||http://dx.doi.org/10.17169/refubium-26239","eng","https://creativecommons.org/licenses/by/4.0/","600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit","obesity||sodium||hypertension||adolescents||MRI||MR-spectroscopy","Tissue Sodium Content and Arterial Hypertension in Obese Adolescents","Wissenschaftlicher Artikel","open access","2036","10.3390/jcm8122036","Journal of Clinical Medicine","12","MDPI AG","31766426","8","2077-0383","Charité - Universitätsmedizin Berlin","no"