dc.contributor.author
Genov, Nikolai
dc.contributor.author
Castellana, Stefano
dc.contributor.author
Scholkmann, Felix
dc.contributor.author
Capocefalo, Daniele
dc.contributor.author
Truglio, Mauro
dc.contributor.author
Rosati, Jessica
dc.contributor.author
Turco, Elisa Maria
dc.contributor.author
Biagini, Tommaso
dc.contributor.author
Carbone, Annalucia
dc.contributor.author
Mazza, Tommaso
dc.contributor.author
Relógio, Angela
dc.contributor.author
Mazzoccoli, Gianluigi
dc.date.accessioned
2020-01-20T13:38:29Z
dc.date.available
2020-01-20T13:38:29Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/26456
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-26216
dc.description.abstract
Cellular, organ, and whole animal physiology show temporal variation predominantly featuring 24-h (circadian) periodicity. Time-course mRNA gene expression profiling in mouse liver showed two subsets of genes oscillating at the second (12-h) and third (8-h) harmonic of the prime (24-h) frequency. The aim of our study was to identify specific genomic, proteomic, and functional properties of ultradian and circadian subsets. We found hallmarks of the three oscillating gene subsets, including different (i) functional annotation, (ii) proteomic and electrochemical features, and (iii) transcription factor binding motifs in upstream regions of 8-h and 12-h oscillating genes that seemingly allow the link of the ultradian gene sets to a known circadian network. Our multifaceted bioinformatics analysis of circadian and ultradian genes suggests that the different rhythmicity of gene expression impacts physiological outcomes and may be related to transcriptional, translational and post-translational dynamics, as well as to phylogenetic and evolutionary components.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
biological clock
en
dc.subject
rhythmic gene expression
en
dc.subject
rhythmic protein expression
en
dc.subject
circadian rhythms
en
dc.subject
ultradian rhythms
en
dc.subject
electrochemical features
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
A Multi-Layered Study on Harmonic Oscillations in Mammalian Genomics and Proteomics
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
4585
dcterms.bibliographicCitation.doi
10.3390/ijms20184585
dcterms.bibliographicCitation.journaltitle
International Journal of Molecular Sciences
dcterms.bibliographicCitation.number
18
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
20
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31533246
dcterms.isPartOf.eissn
1422-0067