dc.contributor.author
Speck, Lucas G.
dc.contributor.author
Schöner, Johanna
dc.contributor.author
Bermpohl, Felix
dc.contributor.author
Heinz, Andreas
dc.contributor.author
Gallinat, Jürgen
dc.contributor.author
Majić, Tomislav
dc.contributor.author
Montag, Christiane
dc.date.accessioned
2019-06-12T12:58:45Z
dc.date.available
2019-06-12T12:58:45Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24757
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2517
dc.description.abstract
Oxytocin (OXT) is critically involved in the regulation of attachment and interpersonal function. In this study, emotional childrens movies were used to stimulate OXT secretion in patients with schizophrenia and healthy controls (HCs). Furthermore, associations of OXT levels with measures of attachment style (Psychosis Attachment Measure), childhood adversity (Childhood Trauma Questionnaire) and symptom severity [Positive and Negative Syndrome Scale (PANSS)] were considered. In 35 patients with schizophrenia and 35 matched HCs, radioimmunoassay with sample extraction was used to determine OXT plasma levels before and after viewing of movie scenes portraying emotional bonding and loss and compared to a non-emotional condition. Statistical analysis indicated lower baseline OXT levels in female patients than in all other groups. OXT reactivity during emotional movies was significantly higher in patients when compared to HCs. OXT reactivity during the control movie related to PANSS `general psychopathology. No significant associations appeared between baseline or induced OXT levels and other PANSS subscales, attachment style or childhood adversity in patients. Our findings suggest differences of baseline OXT and a higher OXT reactivity toward strong emotional stimuli in patients with schizophrenia, suggesting a role of OXT as a gender- and context-dependent modulator of socio-emotional function.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
schizophrenia
en
dc.subject
emotion induction
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Endogenous oxytocin response to film scenes of attachment and loss is pronounced in schizophrenia
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1093/scan/nsy110
dcterms.bibliographicCitation.journaltitle
Social Cognitive and Affective Neuroscience
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
Oxford University Press
dcterms.bibliographicCitation.pagestart
109
dcterms.bibliographicCitation.pageend
117
dcterms.bibliographicCitation.volume
14
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
30481342
dcterms.isPartOf.issn
1749-5024