dc.contributor.author
Hansing, Johann
dc.contributor.author
Netz, Roland R.
dc.date.accessioned
2019-06-06T06:14:03Z
dc.date.available
2019-06-06T06:14:03Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24682
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2442
dc.description.abstract
Using stochastic simulations, we study the influence of spatial disorder on the diffusion of a single particle through a gel that consists of rigid, straight fibers. The interaction between the particle and the gel fibers consists of an invariant short-range repulsion, the steric part, and an interaction part that can be attractive or repulsive and of varying range. The effect that spatial disorder of the gel structure has on the particle diffusivity depends crucially on the presence of nonsteric interactions. For attractive interactions, disorder slows down diffusion, because in disordered gels, the particle becomes strongly trapped in regions of locally increased fiber density. For repulsive interactions, the diffusivity is minimal for intermediate disorder strength, because highly disordered lattices exhibit abundant passageways of locally low fiber density. The comparison with experimental data on protein and fluorophore diffusion through various hydrogels is favorable. Our findings shed light on particle-diffusion mechanisms in biogels and thus on biological barrier properties, which can be helpful for the optimal design of synthetic diffusors as well as synthetic mucus constructs
en
dc.subject
stochastic simulations
en
dc.subject
diffusion of a single particle
en
dc.subject
spatial disorder
en
dc.subject
synthetic diffusors
en
dc.subject
synthetic mucus constructs
en
dc.subject.ddc
500 Natural sciences and mathematics::530 Physics::530 Physics
dc.title
Particle Trapping Mechanisms Are Different in Spatially Ordered and Disordered Interacting Gels
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1016/j.bpj.2018.04.041
dcterms.bibliographicCitation.journaltitle
Biophysical Journal
dcterms.bibliographicCitation.number
11
dcterms.bibliographicCitation.pagestart
2653
dcterms.bibliographicCitation.pageend
2664
dcterms.bibliographicCitation.volume
114
dcterms.bibliographicCitation.url
https://doi.org/10.1016/j.bpj.2018.04.041
dcterms.rightsHolder.note
Copyright des Verlages
dcterms.rightsHolder.url
https://www.cell.com/rights-sharing-embargoes
refubium.affiliation
Physik
refubium.affiliation.other
Institut für Theoretische Physik

refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
0006-3495
dcterms.isPartOf.eissn
1542-0086