Objective: Mortality due to intensive care unit (ICU) acquired primary blood stream infections (PBSI) is related primarily to patient co-morbidities, types of pathogens and quality of care. The objective of this study is to determine the impact of various types of pathogen on ICU mortality. Methods: Data from the German National Nosocomial Infection Surveillance System of patients with PBSI from 2006 to 2015 was used for this analysis. A BSI is primary when the pathogen recognized is not related to an infection on another site. Only mono-microbial infections stratified into the 13 pathogens most frequently causing PBSI were considered. Univariate and multivariate risk factor analyses were performed using the following risk factors: Sex, age, length of stay, device use, time until onset of PBSI, type and size of hospital, type of ICU and type of pathogen. ICU mortality following S. aureus PBSI was used as the reference value. Results: A total of 4,556,360 patients with 16,978,882 patient days from 937 ICUs were considered in the analysis. Of 14,626 PBSI in total, 12,745 mono-microbial PBSI were included. The ICU mortality was 18.6%. Compared with S. aureus and adjusted by age, sex and type of ICU, S. maltophlfia was associated with significantly higher ICU mortality (OR 1.71; 95% CI 1.19-2.47) as followed by Enterococci (OR 1.20; 95% CI 1.06-1.36), Ecoli (OR 1.24; 95% CI 1.02-1.49), C. albicans (OR 1.37; 95% CI 1.16-1.61), non albicans Candida spp. (OR 1.49; 95% CI 1.18-1.88) and P. aeruginosa (OR 1.49; 95% CI 1.21-1.84). Coagulase negative Staphylococci were associated with significant lower ICU mortality (OR 0.86; 95% Cl 0.75-0.99). Conclusion: Because of the limitation of the study in adjusting for severity of illness and appropriateness of therapy, the differences between the pathogens may not only be explained by differences in virulence, but may reflect the prognosis after receiving the microbiological results and may therefore be useful for intensive care physicians.