dc.contributor.author
Bereswill, Stefan
dc.contributor.author
Ekmekciu, Ira
dc.contributor.author
Escher, Ulrike
dc.contributor.author
Fiebiger, Ulrike
dc.contributor.author
Stingl, Kerstin
dc.contributor.author
Heimesaat, Markus M.
dc.date.accessioned
2018-06-08T10:47:01Z
dc.date.available
2017-06-15T09:37:56.197Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21080
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24377
dc.description.abstract
Campylobacter jejuni infections are progressively increasing worldwide.
Probiotic treatment might open novel therapeutic or even prophylactic
approaches to combat campylobacteriosis. In the present study secondary
abiotic mice were generated by broad-spectrum antibiotic treatment and
perorally reassociated with a commensal murine Lactobacillus johnsonii strain
either 14 days before (i.e. prophylactic regimen) or 7 days after (i.e.
therapeutic regimen) peroral C. jejuni strain 81–176 infection. Following
peroral reassociation both C. jejuni and L. johnsonii were able to stably
colonize the murine intestinal tract. Neither therapeutic nor prophylactic L.
johnsonii application, however, could decrease intestinal C. jejuni burdens.
Notably, C. jejuni induced colonic apoptosis could be ameliorated by
prophylactic L. johnsonii treatment, whereas co-administration of L. johnsonii
impacted adaptive (i.e. T and B lymphocytes, regulatory T cells), but not
innate (i.e. macrophages and monocytes) immune cell responses in the
intestinal tract. Strikingly, C. jejuni induced intestinal, extra-intestinal
and systemic secretion of pro-inflammatory mediators (such as IL-6, MCP-1, TNF
and nitric oxide) could be alleviated by peroral L. johnsonii challenge. In
conclusion, immunomodulatory probiotic species might offer valuable strategies
for prophylaxis and/or treatment of C. jejuni induced intestinal, extra-
intestinal as well as systemic pro-inflammatory immune responses in vivo.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Mucosal immunology
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Lactobacillus johnsonii ameliorates intestinal, extra-intestinal and systemic
pro-inflammatory immune responses following murine Campylobacter jejuni
infection
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Scientific Reports. - 7 (2017), Artikel Nr. 2138
dcterms.bibliographicCitation.doi
10.1038/s41598-017-02436-2
dcterms.bibliographicCitation.url
http://www.nature.com/articles/s41598-017-02436-2
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000027188
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008324
dcterms.accessRights.openaire
open access