dc.contributor.author
Edemann-Callesen, Henriette
dc.contributor.author
Habelt, Bettina
dc.contributor.author
Wieske, Franziska
dc.contributor.author
Jackson, Mark
dc.contributor.author
Khadka, Niranjan
dc.contributor.author
Mattei, Daniele
dc.contributor.author
Bernhardt, Nadine
dc.contributor.author
Heinz, Andreas
dc.contributor.author
Liebetanz, David
dc.contributor.author
Bikson, Marom
dc.contributor.author
Padberg, Frank
dc.contributor.author
Hadar, Ravit
dc.contributor.author
Nitsche, Michael A.
dc.contributor.author
Winter, Christine
dc.date.accessioned
2018-06-08T10:39:44Z
dc.date.available
2018-03-01T11:58:47.498Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20840
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24139
dc.description.abstract
Involuntary movements as seen in repetitive disorders such as Tourette
Syndrome (TS) results from cortical hyperexcitability that arise due to
striato-thalamo-cortical circuit (STC) imbalance. Transcranial direct current
stimulation (tDCS) is a stimulation procedure that changes cortical
excitability, yet its relevance in repetitive disorders such as TS remains
largely unexplored. Here, we employed the dopamine transporter-overexpressing
(DAT-tg) rat model to investigate behavioral and neurobiological effects of
frontal tDCS. The outcome of tDCS was pathology dependent, as anodal tDCS
decreased repetitive behavior in the DAT-tg rats yet increased it in wild-type
(wt) rats. Extensive deep brain stimulation (DBS) application and
computational modeling assigned the response in DAT-tg rats to the
sensorimotor pathway. Neurobiological assessment revealed cortical activity
changes and increase in striatal inhibitory properties in the DAT-tg rats. Our
findings show that tDCS reduces repetitive behavior in the DAT-tg rat through
modulation of the sensorimotor STC circuit. This sets the stage for further
investigating the usage of tDCS in repetitive disorders such as TS.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Psychiatric disorders
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Non-invasive modulation reduces repetitive behavior in a rat model through the
sensorimotor cortico-striatal circuit
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Translational Psychiatry. - 8 (2018), Artikel Nr. 11
dcterms.bibliographicCitation.doi
10.1038/s41398-017-0059-5
dcterms.bibliographicCitation.url
http://www.nature.com/articles/s41398-017-0059-5
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000029167
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000009497
dcterms.accessRights.openaire
open access