dc.contributor.author
Lupo, Philip J.
dc.contributor.author
Danysh, Heather E.
dc.contributor.author
Plon, Sharon E.
dc.contributor.author
Curtin, Karen
dc.contributor.author
Malkin, David
dc.contributor.author
Hettmer, Simone
dc.contributor.author
Hawkins, Douglas S.
dc.contributor.author
Skapek, Stephen X.
dc.contributor.author
Spector, Logan G.
dc.contributor.author
Papworth, Karin
dc.contributor.author
Melin, Beatrice
dc.contributor.author
Erhardt, Erik B.
dc.contributor.author
Grufferman, Seymour
dc.contributor.author
Schiffman, Joshua D.
dc.date.accessioned
2018-06-08T03:35:55Z
dc.date.available
2015-06-26T07:37:52.336Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15525
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19713
dc.description.abstract
Relatively little is known about the epidemiology and factors underlying
susceptibility to childhood rhabdomyosarcoma (RMS). To better characterize
genetic susceptibility to childhood RMS, we evaluated the role of family
history of cancer using data from the largest case–control study of RMS and
the Utah Population Database (UPDB). RMS cases (n = 322) were obtained from
the Children's Oncology Group (COG). Population-based controls (n = 322) were
pair-matched to cases on race, sex, and age. Conditional logistic regression
was used to evaluate the association between family history of cancer and
childhood RMS. The results were validated using the UPDB, from which 130 RMS
cases were identified and matched to controls (n = 1300) on sex and year of
birth. The results were combined to generate summary odds ratios (ORs) and 95%
confidence intervals (CI). Having a first-degree relative with a cancer
history was more common in RMS cases than controls (ORs = 1.39, 95% CI:
0.97–1.98). Notably, this association was stronger among those with embryonal
RMS (ORs = 2.44, 95% CI: 1.54–3.86). Moreover, having a first-degree relative
who was younger at diagnosis of cancer (<30 years) was associated with a
greater risk of RMS (ORs = 2.37, 95% CI: 1.34–4.18). In the largest analysis
of its kind, we found that most children diagnosed with RMS did not have a
family history of cancer. However, our results indicate an increased risk of
RMS (particularly embryonal RMS) in children who have a first-degree relative
with cancer, and among those whose relatives were diagnosed with cancer at <30
years of age.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Childhood cancer
dc.subject
family history
dc.subject
rhabdomyosarcoma
dc.subject
soft tissue sarcoma
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
dc.title
Family history of cancer and childhood rhabdomyosarcoma
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Cancer Medicine. - 4 (2015), 5, S. 781–790
dc.title.subtitle
a report from the Children's Oncology Group and the Utah Population Database
dcterms.bibliographicCitation.doi
10.1002/cam4.448
dcterms.bibliographicCitation.url
http://onlinelibrary.wiley.com/doi/10.1002/cam4.448/abstract;jsessionid=8B1136B4579932D59DDAC79B14934944.f04t01
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000022704
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005105
dcterms.accessRights.openaire
open access