dc.contributor.author
Khandare, Jayant
dc.contributor.author
Calderón, Marcelo
dc.contributor.author
Dagia, Nilesh M.
dc.contributor.author
Haag, Rainer
dc.date.accessioned
2018-06-08T02:59:06Z
dc.date.available
2016-09-01T11:39:28.030Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14265
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18460
dc.description.abstract
Nanotechnology has resulted in materials that have greatly improved the
effectiveness of drug delivery because of their ability to control matter on
the nanoscale. Advanced forms of nanomedicine have been synthesized for better
pharmacokinetics to obtain higher efficacy, less systemic toxicity, and better
targeting. These criteria have long been the goal in nanomedicine, in
particular, for systemic applications in oncological disorders. Now, the “holy
grail” in nanomedicine is to design and synthesize new advanced macromolecular
nanocarriers and to translate them from lab to clinic. This review describes
the current and future perspectives of nanomedicine with particular emphasis
on the clinical targets in cancer and inflammation. The advanced forms of
liposomes and polyethylene glycol (PEG) based nanocarriers, as well as
dendritic polymer conjugates will be discussed with particular attention paid
to designs, synthetic strategies, and chemical pathways. In this critical
review, we also report on the current status and perspective of dendritic
polymer nanoconjugate platforms (e.g. polyamidoamine dendrimers and dendritic
polyglycerols) for cellular localization and targeting of specific tissues
(192 references).
en
dc.format.extent
26 Seiten
dc.rights.uri
http://www.rsc.org/journals-books-databases/open-access/green-open-access/
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::572 Biochemie
dc.title
Multifunctional dendritic polymers in nanomedicine: opportunities and
challenges
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Chem. Soc. Rev. -41 (2012), 7, S. 2824-2848
dcterms.bibliographicCitation.doi
10.1039/C1CS15242D
dcterms.bibliographicCitation.url
http://pubs.rsc.org/en/content/articlelanding/2012/cs/c1cs15242d#!divAbstract
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.mycore.fudocsId
FUDOCS_document_000000025136
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006886
dcterms.accessRights.openaire
open access