Title:
Continuous Synthesis of Artemisinin-Derived Medicines
Author(s):
Gilmore, Kerry; Kopetzki, Daniel; Lee, Ju Weon; Horváth, Zoltán; McQuade, D. Tyler; Seidel-Morgenstern, Andreas; Seeberger, Peter H.
Year of publication:
2014
Available Date:
2014-10-16T11:48:24.212Z
Abstract:
Described is a continuous, divergent synthesis system which is coupled to
continuous purification and is capable of producing four anti-malarial APIs.
The system is comprised of three linked reaction modules for
photooxidation/cyclization, reduction, and derivatization. A fourth module
couples the crude reaction stream with continuous purification to yield pure
API.
DDC-Classification:
540 Chemie
Publication Type:
Wissenschaftlicher Artikel
Also published in:
Chem. Commun. - (2014), 50,S. 12652 - 12655
URL of the Original Publication:
DOI of the Original Publication:
Department/institution:
Biologie, Chemie, Pharmazie
Comments:
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
