Title:
Fabrication of thermoresponsive nanogels by thermo-nanoprecipitation and in
situ encapsulation of bioactives
Author(s):
Giulbudagian, Michael; Asadian-Birjand, Mazdak; Steinhilber, Dirk; Achazi, Katharina; Molina, Maria; Calderón, Marcelo
Year of publication:
2015
Available Date:
2015-03-05T13:05:19.571Z
Abstract:
A synthetic method for thermoresponsive, glycerol based nanogels has been
developed. The nanogels were synthesized by nanoprecipitation of the
orthogonally functionalized macromonomers and their gelation in water. The
crosslinking points were generated by strain promoted azide–alkyne
cycloaddition which enabled the in situ encapsulation of Doxorubicin HCl. The
mild and surfactant free reaction conditions make these nanogels ideal
candidates for biomedical applications.
DDC-Classification:
540 Chemie
Publication Type:
Wissenschaftlicher Artikel
Also published in:
Polymer Chemistry. - 5 (2015), 24, S. 6909-6913
URL of the Original Publication:
DOI of the Original Publication:
Department/institution:
Biologie, Chemie, Pharmazie
