A synthetic method for thermoresponsive, glycerol based nanogels has been
developed. The nanogels were synthesized by nanoprecipitation of the
orthogonally functionalized macromonomers and their gelation in water. The
crosslinking points were generated by strain promoted azide–alkyne
cycloaddition which enabled the in situ encapsulation of Doxorubicin HCl. The
mild and surfactant free reaction conditions make these nanogels ideal
candidates for biomedical applications.