dc.contributor.author
Feldmann, Lucia K.
dc.contributor.author
Lofredi, Roxanne
dc.contributor.author
Al‐Fatly, Bassam
dc.contributor.author
Busch, Johannes L.
dc.contributor.author
Mathiopoulou, Varvara
dc.contributor.author
Roediger, Jan
dc.contributor.author
Krause, Patricia
dc.contributor.author
Schneider, Gerd‐Helge
dc.contributor.author
Faust, Katharina
dc.contributor.author
Horn, Andreas
dc.contributor.author
Kühn, Andrea A.
dc.contributor.author
Neumann, Wolf‐Julian
dc.date.accessioned
2025-12-08T15:17:16Z
dc.date.available
2025-12-08T15:17:16Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/50710
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-50437
dc.description.abstract
Background
Subthalamic nucleus (STN) beta (13 - 35 Hz) activity is a biomarker reflecting motor state in Parkinson's disease (PD). Adaptive deep brain stimulation (DBS) aims to use beta activity for therapeutic adjustments, but many aspects of beta activity in real-life situations are unknown.
Objective
The aim was to investigate Christmas-related influences on beta activity in PD.
Methods
Differences in Christmas Day to nonfestive daily averages in chronic biomarker recordings in 4 PD patients with a sensing-enabled STN DBS implant were retrospectively analyzed. Sweet-spot and whole-brain network connectomic analyses were performed.
Results
Beta activity was significantly reduced on Christmas Eve in all patients (4.00–9.00 p.m.: −12.30 ± 10.78%, P = 0.015). A sweet spot in the dorsolateral STN connected recording sites to motor, premotor, and supplementary motor cortices.
Conclusions
We demonstrate that festive events can reduce beta biomarker activity. We conclude that circadian and holiday-related changes should be considered when tailoring adaptive DBS algorithms to patient demands.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
adaptive deep brain stimulation
en
dc.subject
basal ganglia
en
dc.subject
movement disorders
en
dc.subject
neurophysiology
en
dc.subject
Parkinson's disease
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Christmas‐Related Reduction in Beta Activity in Parkinson's Disease
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1002/mds.29334
dcterms.bibliographicCitation.journaltitle
Movement Disorders
dcterms.bibliographicCitation.number
4
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.pagestart
692
dcterms.bibliographicCitation.pageend
697
dcterms.bibliographicCitation.volume
38
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
36718788
dcterms.isPartOf.issn
0885-3185
dcterms.isPartOf.eissn
1531-8257
