dc.contributor.author
Steinert, Carolin
dc.contributor.author
Pashuk, Margarita
dc.contributor.author
Kolkhir, Pavel
dc.contributor.author
Kocatürk, Emek
dc.contributor.author
Xiang, Yi-Kui
dc.date.accessioned
2025-10-29T06:35:26Z
dc.date.available
2025-10-29T06:35:26Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/50041
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-49766
dc.description.abstract
Purpose of the Review
This review aims to educate allergists about the concept of autoallergy by addressing five questions: 1) What is autoallergy and how does it differ from classical allergy? 2) How common is autoallergy? 3) Is autoallergy clinically relevant? 4) How can autoallergy be diagnosed? and 5) How is autoallergy treated?
Recent Findings
In contrast to type I hypersensitivity against external allergens (allergy), autoallergy involves IgE autoantibodies targeting self-antigens. These are found in conditions like chronic spontaneous urticaria, atopic dermatitis, and asthma, with varying prevalence. While no standardized diagnostic tools exist, ELISA and basophil activation tests help identify the presence and function of IgE autoantibodies. Anti-IgE therapies have shown benefit, supporting their clinical relevance.
Summary
Autoallergy is emerging as a distinct IgE-mediated mechanism that may contribute to chronic inflammation in immune-mediated diseases. Further investigation of this mechanism can improve disease stratification and enable more effective, targeted treatment strategies.
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dc.format.extent
12 Seiten
dc.rights
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Atopic dermatitis
en
dc.subject
Chronic spontaneous urticaria
en
dc.subject
Autoantibodies
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
Autoallergy and what the Allergist Needs to know
dc.type
Wissenschaftlicher Artikel
dc.date.updated
2025-10-28T12:38:35Z
dcterms.bibliographicCitation.articlenumber
34
dcterms.bibliographicCitation.doi
10.1007/s11882-025-01215-8
dcterms.bibliographicCitation.journaltitle
Current Allergy and Asthma Reports
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.volume
25
dcterms.bibliographicCitation.url
https://doi.org/10.1007/s11882-025-01215-8
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1529-7322
dcterms.isPartOf.eissn
1534-6315
refubium.resourceType.provider
DeepGreen
