dc.contributor.author
Turan, Tabael L.
dc.contributor.author
Klein, Holger J.
dc.contributor.author
Graf, Theresia Reding
dc.contributor.author
Chillon, Thilo Samson
dc.contributor.author
Plock, Jan A.
dc.contributor.author
Schomburg, Lutz
dc.date.accessioned
2025-07-10T09:53:15Z
dc.date.available
2025-07-10T09:53:15Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/48196
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-47918
dc.description.abstract
The liver-derived selenium (Se) transporter selenoprotein P (SELENOP) declines in critical illness as a negative acute phase reactant and has recently been identified as an autoantigen. Hepatic selenoprotein biosynthesis and cotranslational selenocysteine insertion are sensitive to inflammation, therapeutic drugs, Se deficiency, and other modifiers. As severe burn injury induces a heavy inflammatory burden with concomitant Se depletion, we hypothesized an impairment of selenoprotein biosynthesis in the acute post-burn phase, potentially triggering the development of autoantibodies to SELENOP (SELENOP-aAb). To test this hypothesis, longitudinal serum samples from severely burned patients were analyzed over a period of six months. Newly occurring SELENOP-aAb were detected in 8.4% (7/83) of the burn patients, with onset not earlier than two weeks after injury. Prevalence of SELENOP-aAb was associated with injury severity, as aAb-positive patients have suffered more severe burns than their aAb-negative counterparts (median [IQR] ABSI: 11 [7-12] vs. 7 [5.8-8], p = 0.023). Autoimmunity to SELENOP was not associated with differences in total serum Se or SELENOP concentrations. A positive correlation of kidney-derived glutathione peroxidase (GPx3) with serum SELENOP was not present in the patients with SELENOP-aAb, who showed delayed normalization of GPx3 activity post-burn. Overall, the data suggest that SELENOP-aAb emerge after severe injury in a subset of patients and have antagonistic effects on Se transport. The nature of burn injury as a sudden event allowed a time-resolved analysis of a direct trigger for new-onset SELENOP-aAb, which may be relevant for severely affected patients requiring intensified acute and long-term care.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
autoimmunity
en
dc.subject
glutathione peroxidase
en
dc.subject
critical disease
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
New-onset autoantibodies to selenoprotein P following severe burn injury
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1422781
dcterms.bibliographicCitation.doi
10.3389/fimmu.2024.1422781
dcterms.bibliographicCitation.journaltitle
Frontiers in Immunology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
15
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
39176084
dcterms.isPartOf.eissn
1664-3224