Der Richter und sein Henker: Boten-RNA-Abbau am Ribosom durch CCR4-NOT

Abstract

mRNA decay is a key process controlling cellular protein levels and homeostasis. Cells tune mRNA stability by selective degradation, a process traditionally thought to rely on recognition of mRNA sequence features by proteins or complementary RNAs. By contrast, recent work showed how mRNA translation by the ribosome can direct selective mRNA decay. The ribosome reads out the codon composition and produces the nascent protein, both of which can be used to trigger decay via the CCR4-NOT complex.