dc.contributor.author
Kottner, Jan
dc.contributor.author
Hillmann, Kathrin
dc.contributor.author
Fastner, Alexandra
dc.contributor.author
Conzade, Romy
dc.contributor.author
Heidingsfelder, Stephanie
dc.contributor.author
Neumann, Konrad
dc.contributor.author
Blume‐Peytavi, Ulrike
dc.contributor.author
ADAPI Study Group
dc.date.accessioned
2025-03-28T14:51:45Z
dc.date.available
2025-03-28T14:51:45Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/47069
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-46786
dc.description.abstract
Background
It has been proposed that regular emollient application in early life could enhance skin barrier function and prevent atopic dermatitis (AD) especially in predisposed infants. This hypothesis was supported by evidence from exploratory and pilot trials showing protective effects in terms of reduced cumulative atopic dermatitis incidence with the use of daily emollient therapy starting immediately after birth.
Objectives
To investigate the effectiveness of a standardized skin care regimen for infants on the development of AD compared to not structured skin care regimen in infants with atopic predisposition.
Methods
Prospective, parallel group, randomized, pragmatic, investigator-blinded intervention trial including 160 infants with 52 weeks intervention and 52 weeks follow up phase up to the age of two years. Infants were randomly assigned to receive a standardized skin care regimen including once daily leave-on product application (lipid content 21%) or skin care as preferred by the parents.
Results
Using the intention to treat approach, the cumulative AD incidence was 10.6% after one year, and 19.5% after two years in the total sample. There were no statistical significant differences between intervention and control groups. Skin barrier parameters between the intervention and control groups were comparable. AD severity was higher and quality of life was more affected in the control group.
Conclusions
Regular emollient application during the first year of life does not prevent the development of atopic dermatitis. A standardized skin care regimen does not delay skin barrier development or causes side effects.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
atopic dermatitis (AD)
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Effectiveness of a standardized skin care regimen to prevent atopic dermatitis in infants at risk for atopy: A randomized, pragmatic, parallel-group study
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1111/jdv.18698
dcterms.bibliographicCitation.journaltitle
Journal of the European Academy of Dermatology and Venereology
dcterms.bibliographicCitation.number
3
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.pagestart
540
dcterms.bibliographicCitation.pageend
548
dcterms.bibliographicCitation.volume
37
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
36308037
dcterms.isPartOf.issn
0926-9959
dcterms.isPartOf.eissn
1468-3083