dc.contributor.author
Zhou, Sijia
dc.contributor.author
Maleitzke, Tazio
dc.contributor.author
Geissler, Sven
dc.contributor.author
Hildebrandt, Alexander
dc.contributor.author
Fleckenstein, Florian Nima
dc.contributor.author
Niemann, Marcel
dc.contributor.author
Fischer, Heilwig
dc.contributor.author
Perka, Carsten
dc.contributor.author
Duda, Georg N.
dc.contributor.author
Winkler, Tobias
dc.date.accessioned
2025-03-26T15:26:55Z
dc.date.available
2025-03-26T15:26:55Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/47048
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-46765
dc.description.abstract
Knee osteoarthritis, the most prevalent degenerative joint disorder worldwide, is driven by chronic low-grade inflammation and subsequent cartilage degradation. Clinical data on the role of the Hoffa or infrapatellar fat pad in knee osteoarthritis are, however, scarce. The infrapatellar fat pad is a richly innervated intracapsular, extrasynovial adipose tissue, and an abundant source of adipokines and proinflammatory and catabolic cytokines, which may contribute to chronic synovial inflammation, cartilage destruction, and subchondral bone remodeling during knee osteoarthritis. How the infrapatellar fat pad interacts with neighboring tissues is poorly understood. Here, we review available literature with regard to the infrapatellar fat pad's interactions with cartilage, synovium, bone, menisci, ligaments, and nervous tissue during the development and progression of knee osteoarthritis. Signaling cascades are described with a focus on immune cell populations, pro- and anti-inflammatory cytokines, adipokines, mesenchymal stromal cells, and molecules derived from conditioned media from the infrapatellar fat pad. Understanding the complex interplay between the infrapatellar fat pad and its neighboring articular tissues may help to better understand and treat the multifactorial pathogenesis of osteoarthritis.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
immune cells
en
dc.subject
mesenchymal stromal cells
en
dc.subject
subchondral bone
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Source and hub of inflammation: The infrapatellar fat pad and its interactions with articular tissues during knee osteoarthritis
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1002/jor.25347
dcterms.bibliographicCitation.journaltitle
Journal of Orthopaedic Research
dcterms.bibliographicCitation.number
7
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.pagestart
1492
dcterms.bibliographicCitation.pageend
1504
dcterms.bibliographicCitation.volume
40
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
35451170
dcterms.isPartOf.issn
0736-0266
dcterms.isPartOf.eissn
1554-527X