dc.contributor.author
Kanwal, Sidra
dc.contributor.author
Aziz, Umer Bin Abdul
dc.contributor.author
Quaas, Elisa
dc.contributor.author
Achazi, Katharina
dc.contributor.author
Klinger, Daniel
dc.date.accessioned
2025-02-13T07:46:44Z
dc.date.available
2025-02-13T07:46:44Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/46576
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-46290
dc.description.abstract
We are facing a shortage of new antibiotics to fight against increasingly resistant bacteria. As an alternative to conventional small molecule antibiotics, antimicrobial polymers (AMPs) have great potential. These polymers contain cationic and hydrophobic groups and disrupt bacterial cell membranes through a combination of electrostatic and hydrophobic interactions. While most examples focus on ammonium-based cations, sulfonium groups are recently emerging to broaden the scope of polymeric therapeutics. Here, main-chain sulfonium polymers exhibit good antimicrobial activity. In contrast, the potential of side-chain sulfonium polymers remains less explored with structure–activity relationships still being limited. To address this limitation, we thoroughly investigated key factors influencing antimicrobial activity in side-chain sulfonium-based AMPs. For this, we combined sulfonium cations with different hydrophobic (aliphatic/aromatic) and hydrophilic polyethylene glycol (PEG) groups to create a library of polymers with comparable chain lengths. For all compositions, we additionally examined the position of cationic and hydrophobic groups on the polymer backbone, i.e. , we systematically compared same center and different center structures. Bactericidal tests against Gram-positive and Gram-negative bacteria suggest that same center polymers are more active than different center polymers of similar clog P . Ultimately, sulfonium-based AMPs show superior bactericidal activity and selectivity when compared to their quaternary ammonium cationic analogues.
en
dc.format.extent
17 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
new antibiotics
en
dc.subject
antimicrobial polymers
en
dc.subject
sulfonium-based polymethacrylamides
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik
dc.title
Sulfonium-based polymethacrylamides for antimicrobial use: influence of the structure and composition†
dc.type
Wissenschaftlicher Artikel
dc.date.updated
2025-02-12T04:01:30Z
dcterms.bibliographicCitation.doi
10.1039/D4BM01247J
dcterms.bibliographicCitation.journaltitle
Biomaterials Science
dcterms.bibliographicCitation.number
4
dcterms.bibliographicCitation.pagestart
993
dcterms.bibliographicCitation.pageend
1009
dcterms.bibliographicCitation.volume
13
dcterms.bibliographicCitation.url
https://doi.org/10.1039/D4BM01247J
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Pharmazie

refubium.affiliation.other
Institut für Chemie und Biochemie

refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
2047-4830
dcterms.isPartOf.eissn
2047-4849
refubium.resourceType.provider
DeepGreen