dc.contributor.author
Du, Youlong
dc.contributor.author
Semghouli, Anas
dc.contributor.author
Wang, Qian
dc.contributor.author
Mei, Haibo
dc.contributor.author
Kiss, Loránd
dc.contributor.author
Baecker, Daniel
dc.contributor.author
Soloshonok, Vadim A.
dc.contributor.author
Han, Jianlin
dc.date.accessioned
2025-02-04T08:58:32Z
dc.date.available
2025-02-04T08:58:32Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/46475
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-46188
dc.description.abstract
Macrocycles or medium-sized rings offer diverse functionality and stereochemical complexity in a well-organized ring structure, allowing them to fulfill various biochemical functions, resulting in high affinity and selectivity for protein targets, while preserving sufficient bioavailability to reach intracellular compartments. These features have made macrocycles attractive candidates in organic synthesis and drug discovery. Since the 20th century, more than three-score macrocyclic drugs, including radiopharmaceuticals, have been approved by the US Food and Drug Administration (FDA) for treating bacterial and viral infections, cancer, obesity, immunosuppression, inflammatory, and neurological disorders, managing cardiovascular diseases, diabetes, and more. This review presents 17 FDA-approved macrocyclic drugs during the past 5 years, highlighting their importance and critical role in modern therapeutics, and the innovative synthetic approaches for the construction of these macrocycles.
en
dc.format.extent
24 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
asymmetric synthesis
en
dc.subject
drug design and development
en
dc.subject
FDA-approved drugs
en
dc.subject
macrocyclic drugs
en
dc.subject
peptides and proteins
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik
dc.title
FDA-approved drugs featuring macrocycles or medium-sized rings
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e2400890
dcterms.bibliographicCitation.doi
10.1002/ardp.202400890
dcterms.bibliographicCitation.journaltitle
Archiv der Pharmazie
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.volume
358
dcterms.bibliographicCitation.url
https://doi.org/10.1002/ardp.202400890
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Pharmazie

refubium.funding
DEAL Wiley
refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1521-4184