dc.contributor.author
Lukas, Fabian
dc.contributor.author
Matthaeus, Claudia
dc.contributor.author
López-Hernández, Tania
dc.contributor.author
Lahmann, Ines
dc.contributor.author
Schultz, Nicole
dc.contributor.author
Lehmann, Martin
dc.contributor.author
Puchkov, Dmytro
dc.contributor.author
Pielage, Jan
dc.contributor.author
Haucke, Volker
dc.contributor.author
Maritzen, Tanja
dc.date.accessioned
2025-01-28T12:14:28Z
dc.date.available
2025-01-28T12:14:28Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/46395
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-46108
dc.description.abstract
Adhesions are critical for anchoring cells in their environment, as signaling platforms and for cell migration. In line with these diverse functions different types of cell-matrix adhesions have been described. Best-studied are the canonical integrin-based focal adhesions. In addition, non-canonical integrin adhesions lacking focal adhesion proteins have been discovered. These include reticular adhesions also known as clathrin plaques or flat clathrin lattices, that are enriched in clathrin and other endocytic proteins, as well as extensive adhesion networks and retraction fibers. How these different adhesion types that share a common integrin backbone are related and whether they can interconvert is unknown. Here, we identify the protein stonin1 as a marker for non-canonical αVβ5 integrin-based adhesions and demonstrate by live cell imaging that canonical and non-canonical adhesions can reciprocally interconvert by the selective exchange of components on a stable αVβ5 integrin scaffold. Hence, non-canonical adhesions can serve as points of origin for the generation of canonical focal adhesions.
en
dc.format.extent
15 Seiten
dc.rights
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Cytoskeleton
en
dc.subject
Focal adhesion
en
dc.subject
Integrin signalling
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
Canonical and non-canonical integrin-based adhesions dynamically interconvert
dc.type
Wissenschaftlicher Artikel
dc.date.updated
2025-01-27T10:44:08Z
dcterms.bibliographicCitation.articlenumber
2093
dcterms.bibliographicCitation.doi
10.1038/s41467-024-46381-x
dcterms.bibliographicCitation.journaltitle
Nature Communications
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.volume
15
dcterms.bibliographicCitation.url
https://doi.org/10.1038/s41467-024-46381-x
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie

refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2041-1723
refubium.resourceType.provider
DeepGreen