dc.contributor.author
Meiering, Marvin S.
dc.contributor.author
Weigner, David
dc.contributor.author
Gärtner, Matti
dc.contributor.author
Carstens, Luisa
dc.contributor.author
Keicher, Christian
dc.contributor.author
Hertrampf, Rita
dc.contributor.author
Beckmann, Christian F.
dc.contributor.author
Mennes, Maarten
dc.contributor.author
Wunder, Andreas
dc.contributor.author
Weigand, Anne
dc.contributor.author
Grimm, Simone
dc.date.accessioned
2025-01-28T10:09:12Z
dc.date.available
2025-01-28T10:09:12Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/46390
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-46102
dc.description.abstract
Ketamine is a highly effective antidepressant (AD) that targets the glutamatergic system and exerts profound effects on brain circuits during negative emotional processing. Interestingly, the effects of ketamine on brain measures are sensitive to modulation by pretreatment with lamotrigine, which inhibits glutamate release. Examining the antagonistic effects of ketamine and lamotrigine on glutamate transmission holds promise to identify effects of ketamine that are mediated through changes in the glutamatergic system. Investigating this modulation in relation to both the acute and sustained effects of ketamine on functional activity and connectivity during negative emotional processing should therefore provide novel insights. 75 healthy subjects were investigated in a double-blind, single-dose, randomized, placebo-controlled, parallel-group study with three treatment conditions (ketamine, lamotrigine pre-treatment, placebo). Participants completed an emotional face viewing task during ketamine infusion and 24 h later. Acute ketamine administration decreased hippocampal and Default Mode Network (DMN) activity and increased fronto-limbic coupling during negative emotional processing. Furthermore, while lamotrigine abolished the ketamine-induced increase in functional connectivity, it had no acute effect on activity. Sustained (24 h later) effects of ketamine were only found for functional activity, with a significant reduction in the posterior DMN. This effect was blocked by pretreatment with lamotrigine. Our results suggest that both the acute increases in fronto-limbic coupling and the delayed decrease in posterior DMN activity, but not the attenuated limbic and DMN recruitment after ketamine, are mediated by altered glutamatergic transmission.
en
dc.format.extent
10 Seiten
dc.rights
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Molecular neuroscience
en
dc.subject.ddc
100 Philosophie und Psychologie::150 Psychologie::150 Psychologie
dc.title
Functional activity and connectivity signatures of ketamine and lamotrigine during negative emotional processing: a double-blind randomized controlled fMRI study
dc.type
Wissenschaftlicher Artikel
dc.date.updated
2025-01-27T05:09:01Z
dcterms.bibliographicCitation.articlenumber
436
dcterms.bibliographicCitation.doi
10.1038/s41398-024-03120-6
dcterms.bibliographicCitation.journaltitle
Translational Psychiatry
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.volume
14
dcterms.bibliographicCitation.url
https://doi.org/10.1038/s41398-024-03120-6
refubium.affiliation
Erziehungswissenschaft und Psychologie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2158-3188
refubium.resourceType.provider
DeepGreen