dc.contributor.author
Genath, Antonia
dc.contributor.author
Hackmann, Carolin
dc.contributor.author
Denkel, Luisa
dc.contributor.author
Weber, Anna
dc.contributor.author
Maechler, Friederike
dc.contributor.author
Kola, Axel
dc.contributor.author
Schwarz, Stefan
dc.contributor.author
Gastmeier, Petra
dc.contributor.author
Leistner, Rasmus
dc.date.accessioned
2025-01-28T09:30:08Z
dc.date.available
2025-01-28T09:30:08Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/46388
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-46100
dc.description.abstract
Introduction
The global increase of multidrug-resistant organisms (MDROs) is one of the most urgent public health threats affecting both humans and animals. The One Health concept emphasizes the interconnectedness of human, animal and environmental health and highlights the need for integrated approaches to combat antimicrobial resistance (AMR). Although the sharing of environments and antimicrobial agents between companion animals and humans poses a risk for MDRO transmission, companion animals have been studied to a lesser extent than livestock animals. This study therefore used core genome multilocus sequence typing (cgMLST) to investigate the genetic relationships and putative transmission of MDROs between humans and pets.
Methods
This descriptive integrated typing study included 252 human isolates, 53 dog isolates and 10 cat isolates collected from 2019 to 2022 at the Charité University Hospital in Berlin, Germany. CgMLST was performed to characterize methicillin-resistant Staphylococcus aureus , vancomycin-resistant enterococci and multidrug-resistant gram-negative bacteria. The genetic diversity of the MDROs of the different host populations was determined and compared based on sequence type and core genome complex type.
Results
Within this study the majority of samples from pets and humans was genetically distinct. However, for some isolates, the number of allelic differences identified by cgMLST was low. Two cases of putative household transmission or shared source of VR E. faecium and MDR E. coli between humans and pets were documented.
Conclusions
The interaction between humans and their pets appears to play a minor role in the spread of the MDROs studied. However, further research is needed. This study emphasizes the importance of comprehensive molecular surveillance and a multidisciplinary One Health approach to understand and contain the spread of MDROs in human and animal populations.
Trial Registration
The study is registered with the German Clinical Trials Register (DRKS00030009).
en
dc.format.extent
13 Seiten
dc.rights
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Multidrug-resistance
en
dc.subject
Molecular typing
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
dc.title
The genetic relationship between human and pet isolates: a core genome multilocus sequence analysis of multidrug-resistant bacteria
dc.type
Wissenschaftlicher Artikel
dc.date.updated
2025-01-26T23:35:40Z
dcterms.bibliographicCitation.articlenumber
107
dcterms.bibliographicCitation.doi
10.1186/s13756-024-01457-7
dcterms.bibliographicCitation.journaltitle
Antimicrobial Resistance & Infection Control
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.volume
13
dcterms.bibliographicCitation.url
https://doi.org/10.1186/s13756-024-01457-7
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Mikrobiologie und Tierseuchen

refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2047-2994
refubium.resourceType.provider
DeepGreen