dc.contributor.author
Vogel, Amelie
dc.contributor.author
Tentschert, Jutta
dc.contributor.author
Pieters, Raymond
dc.contributor.author
Bennet, Francesca
dc.contributor.author
Dirven, Hubert
dc.contributor.author
Berg, Annemijne van den
dc.contributor.author
Lenssen, Esther
dc.contributor.author
Rietdijk, Maartje
dc.contributor.author
Brossell, Dirk
dc.contributor.author
Haase, Andrea
dc.date.accessioned
2025-01-16T09:04:03Z
dc.date.available
2025-01-16T09:04:03Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/46271
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-45983
dc.description.abstract
Background
Human exposure to micro- and nanoplastic particles (MNPs) is inevitable but human health risk assessment remains challenging for several reasons. MNPs are complex mixtures of particles derived from different polymer types, which may contain plenty of additives and/or contaminants. MNPs cover broad size distributions and often have irregular shapes and morphologies. Moreover, several of their properties change over time due to aging/ weathering. Case-by-case assessment of each MNP type does not seem feasible, more straightforward methodologies are needed. However, conceptual approaches for human health risk assessment are rare, reliable methods for exposure and hazard assessment are largely missing, and meaningful data is scarce.
Methods
Here we reviewed the state-of-the-art concerning risk assessment of chemicals with a specific focus on polymers as well as on (nano-)particles and fibres. For this purpose, we broadly screened relevant knowledge including guidance documents, standards, scientific publications, publicly available reports. We identified several suitable concepts such as: (i) polymers of low concern (PLC), (ii) poorly soluble low toxicity particles (PSLT) and (iii) fibre pathogenicity paradigm (FPP). We also aimed to identify promising methods, which may serve as a reasonable starting point for a test strategy.
Results and conclusion
Here, we propose a state-of-the-art modular risk assessment framework for MNPs, focusing primarily on inhalation as a key exposure route for humans that combines several integrated approaches to testing and assessment (IATAs). The framework starts with basic physicochemical characterisation (step 1), followed by assessing the potential for inhalative exposure (step 2) and includes several modules for toxicological assessment (step 3). We provide guidance on how to apply the framework and suggest suitable methods for characterization of physicochemical properties, exposure and hazard assessment. We put special emphasis on new approach methodologies (NAMs) and included grouping, where adequate. The framework has been improved in several iterative cycles by taking into account expert feedback and is currently being tested in several case studies. Overall, it can be regarded as an important step forward to tackle human health risk assessment.
en
dc.format.extent
21 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Microplastics
en
dc.subject
Nanoplastics
en
dc.subject
Human health
en
dc.subject
Risk assessment
en
dc.subject
Integrated approaches to testing and assessment (IATAs)
en
dc.subject
Polymers of low concern (PLC)
en
dc.subject
Poorly soluble low toxicity particles (PSLT)
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
Towards a risk assessment framework for micro- and nanoplastic particles for human health
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
48
dcterms.bibliographicCitation.doi
10.1186/s12989-024-00602-9
dcterms.bibliographicCitation.journaltitle
Particle and Fibre Toxicology
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.volume
21
dcterms.bibliographicCitation.url
https://doi.org/10.1186/s12989-024-00602-9
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Pharmazie

refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1743-8977
refubium.resourceType.provider
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